DRSC/TRiP Functional Genomics Resources

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Protein Alignment GAD1 and Tdc1

DIOPT Version :10

Sequence 1:NP_000808.2 Gene:GAD1 / 2571 HGNCID:4092 Length:594 Species:Homo sapiens
Sequence 2:NP_610226.2 Gene:Tdc1 / 35573 FlyBaseID:FBgn0259977 Length:587 Species:Drosophila melanogaster


Alignment Length:439 Identity:110/439 - (25%)
Similarity:179/439 - (40%) Gaps:78/439 - (17%)


- Green bases have known domain annotations that are detailed below.


Human   119 EVVDILLNYVRKTFDRS-TKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYG-VR 181
            ||:|.:..|.....:|. ...||..:..:||..      :....||..:.:|.|....:..| |.
  Fly    12 EVIDYICQYGTNIEERDVAPTLDPGYLKKLLPA------DAPQSPEPFKDVLEDFEQKIMPGVVH 70

Human   182 TGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWSSK---- 242
            ..||:||....:|.....:.|:.|:|...:..|::...|....:|.|       ::.|.:|    
  Fly    71 WNHPKFFAYFPSGNSFPSVLGDMLSSAIGSIGFSWASCPAAAELETI-------VMNWYAKALGL 128

Human   243 ------DGDGIFSPGGAISN------MYSIMAARYKYFPEVKTKGMAAV------PKLVLFTSEQ 289
                  |..| .:.|||:..      :.|::.||.:...|:  ||..:|      |.|:.:.|.:
  Fly   129 PKAFVSDAPG-STGGGALQGSASECVLVSLITARARAISEL--KGQTSVHDSVFLPSLIAYASRE 190

Human   290 SHYSIKKAGAALGFGTDNVILIKCNERGKIIPADFEAK-----ILEAKQK----GYVPFYVNATA 345
            :|.|::||        ..:.|:|.    :||.||...:     :.:|.|.    |..||:|.||.
  Fly   191 AHSSVEKA--------TKMALVKL----RIIDADEHGRMRVDLLRQAIQNDVNAGLTPFFVVATV 243

Human   346 GTTVYGAFDPIQEIADICEKY-NLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGV 409
            |||...|||.|.||..:|.:. ::|||||.|:.|...:..:.|....|:|.|:|...||:|::..
  Fly   244 GTTGGCAFDDITEIGKVCRQVSSIWLHVDGAYAGNSFILPEMRVFSAGLEYADSFNTNPNKLLLT 308

Human   410 LLQCSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTV 474
            ....||:.|::...|:....:...||   ..::....|.....|...|.....|.|.:::..|..
  Fly   309 NFDASALWVRDVMNLKSALNVNPLYL---RHEHLTGVDYRHYGIPLSRRFRALKLWFVFRTYGIR 370

Human   475 GFENQINKCLELAEYLYAKIKNREEFE-------------MVFNGEPEH 510
            |.:..|...:.||:.....::..|.||             |....||.|
  Fly   371 GLQEYIRNHMALAKKFEMLVRKDERFEVRNDVHLGLVCFRMRTGDEPNH 419

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GAD1NP_000808.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Pyridoxal_deC 144..518 CDD:395219 103/413 (25%)
Tdc1NP_610226.2 Pyridoxal_deC 35..412 CDD:395219 99/407 (24%)
Blue background indicates that the domain is not in the aligned region.

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