DRSC/TRiP Functional Genomics Resources

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Protein Alignment GAD1 and Ddc

DIOPT Version :10

Sequence 1:NP_000808.2 Gene:GAD1 / 2571 HGNCID:4092 Length:594 Species:Homo sapiens
Sequence 2:NP_724163.1 Gene:Ddc / 35190 FlyBaseID:FBgn0000422 Length:510 Species:Drosophila melanogaster


Alignment Length:514 Identity:126/514 - (24%)
Similarity:198/514 - (38%) Gaps:86/514 - (16%)


- Green bases have known domain annotations that are detailed below.


Human   116 FLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLEL-----SDHPESLEQILVDCRDT 175
            |...:||.:..|:....:|..          |.|...|:...|     .:.||..:.::.|....
  Fly    44 FAKTMVDFIAEYLENIRERRV----------LPEVKPGYLKPLIPDAAPEKPEKWQDVMQDIERV 98

Human   176 LKYGVRTGH-PRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQIT---LKKMREI 236
            :..||...| |:|.....|......:..:.|:.......||:..:|....:|.:.   |.||.|:
  Fly    99 IMPGVTHWHSPKFHAYFPTANSYPAIVADMLSGAIACIGFTWIASPACTELEVVMMDWLGKMLEL 163

Human   237 ----VGWSSKDGDGIFSPGGAISNMYSIMAARYKYFPEVKT-----KGMAAVPKLVLFTSEQSHY 292
                :..|...|.|:.....:.|.:.:::.|:.|...|||.     .....:.|||.:.|:|:|.
  Fly   164 PAEFLACSGGKGGGVIQGTASESTLVALLGAKAKKLKEVKELHPEWDEHTILGKLVGYCSDQAHS 228

Human   293 SIKKAGAALGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDPIQ 357
            |:::||...|....:|.......||..:....|..:.|    |.:|||...|.|||...|||.:.
  Fly   229 SVERAGLLGGVKLRSVQSENHRMRGAALEKAIEQDVAE----GLIPFYAVVTLGTTNSCAFDYLD 289

Human   358 EIADICEKYNLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKEKG 422
            |...:..|:|||:|||||:.|...:..::||.:.|||.|:|..:||||.|.|...|||:.:|:..
  Fly   290 ECGPVGNKHNLWIHVDAAYAGSAFICPEYRHLMKGIESADSFNFNPHKWMLVNFDCSAMWLKDPS 354

Human   423 ILQGCNQMCAGYLFQPDKQYDVSYDTGDKA-------IQCGRHVDIFKFWLMWKAKGTVGFENQI 480
            .:...        |..|..| :.:|....|       |..||.....|.|.:.:..|....:..|
  Fly   355 WVVNA--------FNVDPLY-LKHDMQGSAPDYRHWQIPLGRRFRALKLWFVLRLYGVENLQAHI 410

Human   481 NKCLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKL---------- 535
            .:....|:...........||:.  .|.....|||     .|:|   |.:|.|.|          
  Fly   411 RRHCNFAKQFGDLCVADSRFELA--AEINMGLVCF-----RLKG---SNERNEALLKRINGRGHI 465

Human   536 HKVAPKIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLGQDL 594
            |.|..|||.:.                  |.||.|.:......|:::..:|:.....::
  Fly   466 HLVPAKIKDVY------------------FLRMAICSRFTQSEDMEYSWKEVSAAADEM 506

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GAD1NP_000808.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Pyridoxal_deC 144..518 CDD:395219 104/398 (26%)
DdcNP_724163.1 Pyridoxal_deC 70..446 CDD:395219 102/395 (26%)
Blue background indicates that the domain is not in the aligned region.

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