DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GAD1 and amd

DIOPT Version :10

Sequence 1:NP_000808.2 Gene:GAD1 / 2571 HGNCID:4092 Length:594 Species:Homo sapiens
Sequence 2:NP_476592.1 Gene:amd / 35188 FlyBaseID:FBgn0000075 Length:510 Species:Drosophila melanogaster


Alignment Length:523 Identity:133/523 - (25%)
Similarity:217/523 - (41%) Gaps:99/523 - (18%)


- Green bases have known domain annotations that are detailed below.


Human   115 QFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLK-- 177
            :|....:|.:.:|:...  |...||....|..||:.:.   .|:.:.||:.:.:|.|....:|  
  Fly     8 EFGKAAIDYIADYLENI--RDDDVLPNVEPGYLLDLLP---TEMPEEPEAWKDVLGDISRVIKPG 67

Human   178 ------------YGVRTGHPRFFNQ-LSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQIT 229
                        |...|.:|....: |::|..:||.:  |:.|.|.|.:   |:    |:|:.:.
  Fly    68 LTHWQSPHMHAYYPTSTSYPSIVGEMLASGFGVIGFS--WICSPACTEL---EV----VVMDWLA 123

Human   230 --LKKMREIVGWSSKDGDGIFSPGGAISNMYSIMAAR----------YKYFPEVKTKGMAAVPKL 282
              ||........|...|.|:.....:.:.:.:::|||          :....|.:.:|     :|
  Fly   124 KFLKLPAHFQHASDGPGGGVIQGSASEAVLVAVLAAREQAVANYRESHPELSESEVRG-----RL 183

Human   283 VLFTSEQSHYSIKKAGA-------ALGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFY 340
            |.::|:||:..|:|||.       .|..|.|.|:      ||..:....|    |....|.:|..
  Fly   184 VAYSSDQSNSCIEKAGVLAAMPIRLLPAGEDFVL------RGDTLRGAIE----EDVAAGRIPVI 238

Human   341 VNATAGTTVYGAFDPIQEIADICEKYNLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHK 405
            ..||.|||...|:|.|:.::.:||::.:|||||||:.||.....:......|::|.:|:.:|.||
  Fly   239 CVATLGTTGTCAYDDIESLSAVCEEFKVWLHVDAAYAGGAFALEECSDLRKGLDRVDSLNFNLHK 303

Human   406 MMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDI--------F 462
            .|.|...|||:.:::      .|::...  |..|:.|......|...|...||..|        .
  Fly   304 FMLVNFDCSAMWLRD------ANKVVDS--FNVDRIYLKHKHEGQSQIPDFRHWQIPLGRRFRAL 360

Human   463 KFWLMWKAKGTVGFENQINKCLELAEYLYAKIKNREEFEMVFNGEPEHTN-VCFWYIPQSLRGVP 526
            |.|:.::..|..|..|.:.|.:|||:.....:.....||:|   .|.... |||       |...
  Fly   361 KVWITFRTLGAEGLRNHVRKHIELAKQFEQLVLKDSRFELV---APRALGLVCF-------RPKG 415

Human   527 DSPQRREKLHKVAPKIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLG 591
            |:....:.|.::..:.|..|:::  ...|.|       |.|.|:.......|||||..:|||...
  Fly   416 DNEITTQLLQRLMDRKKIYMVKA--EHAGRQ-------FLRFVVCGMDTKASDIDFAWQEIESQL 471

Human   592 QDL 594
            .||
  Fly   472 TDL 474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GAD1NP_000808.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Pyridoxal_deC 144..518 CDD:395219 107/416 (26%)
amdNP_476592.1 Pyridoxal_deC 35..414 CDD:395219 108/423 (26%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.