DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAD1 and b

DIOPT Version :9

Sequence 1:	NP_000808.2	Gene:	GAD1 / 2571	HGNCID:	4092	Length:	594	Species:	Homo sapiens
Sequence 2:	NP_001246025.1	Gene:	b / 34791	FlyBaseID:	FBgn0000153	Length:	575	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	243/545 - (44%)
Similarity:	353/545 - (64%)	Gaps:	17/545 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    54 TNSLEEKSRLVSAFKERQSSKNLLSC--ENSDRDARFRRTETDFSNLFARDLLPAKNGEEQTVQF 116
            |:|..:.:..| ||:  |:||.|.:.  .|::.:.....|:.|.|:..|..  ||...|    .|
  Fly    44 TSSPADSTSTV-AFE--QASKMLANAANNNNNNNNNITSTKDDLSSFVASH--PAAEFE----GF 99

Human   117 LLEVVDILLNY-VRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGV 180
            :...||.::.. |.:..:||:||:::|.|.:|   .:.|:.:|.:..||.:::....|:|:::.|
  Fly   100 IRACVDEIIKLAVFQGTNRSSKVVEWHEPAEL---RQLFDFQLREQGESQDKLRELLRETIRFSV 161

Human   181 RTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGW-SSKDG 244
            :||||.|.|||.:|:|...|.|:|||...|.:::|||:||:|.|||:..|.:||.|||: :...|
  Fly   162 KTGHPYFINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTLMEEQVLAEMRRIVGFPNGGQG 226

Human   245 DGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVPKLVLFTSEQSHYSIKKAGAALGFGTDNVI 309
            ||||.|||:|:|.|:|..|||::.||.|..|:.....|::||||.:|||::|....:|||:|:|.
  Fly   227 DGIFCPGGSIANGYAISCARYRHSPESKKNGLFNAKPLIIFTSEDAHYSVEKLAMFMGFGSDHVR 291

Human   310 LIKCNERGKIIPADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDPIQEIADICEKYNLWLHVDA 374
            .|..||.||:..:|.|.::....:.|:.|..|:|||||||.||||.:..|:::|:|||:|:||||
  Fly   292 KIATNEVGKMRLSDLEKQVKLCLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDA 356

Human   375 AWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPD 439
            |||||.|||:|:||.|||||||:||||||||::....|||..|.:.:.:|..|:...|.||||.|
  Fly   357 AWGGGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKD 421

Human   440 KQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELAEYLYAKIKNREEFEMVF 504
            |.||.|:|||||.|||||..|:||||.|||||||.|.|..:.|...:||:..||::.|..||:|.
  Fly   422 KFYDTSFDTGDKHIQCGRRADVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVL 486

Human   505 NGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAPKIKALMMESGTTMVGYQPQGDKANFFRMV 569
            . .||.||:.|||:|..||.:..:.:..::|||||||:|..|::.|:.|:.|||.....||||:|
  Fly   487 E-SPECTNISFWYVPPGLREMERNREFYDRLHKVAPKVKEGMIKKGSMMITYQPLRQLPNFFRLV 550

Human   570 ISNPAATQSDIDFLIEEIERLGQDL 594
            :.|....:||:.:.::|||.|.|:|
  Fly   551 LQNSCLEESDMVYFLDEIESLAQNL 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAD1	NP_000808.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Pyridoxal_deC	144..518	CDD:365998	185/374 (49%)
		Substrate binding	190..192		1/1 (100%)
b	NP_001246025.1	AAT_I	128..499	CDD:302748	185/374 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X464
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920