DRSC/TRiP Functional Genomics Resources

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Protein Alignment GAD1 and Tdc2

DIOPT Version :10

Sequence 1:NP_000808.2 Gene:GAD1 / 2571 HGNCID:4092 Length:594 Species:Homo sapiens
Sequence 2:NP_724489.1 Gene:Tdc2 / 246620 FlyBaseID:FBgn0050446 Length:637 Species:Drosophila melanogaster


Alignment Length:503 Identity:119/503 - (23%)
Similarity:215/503 - (42%) Gaps:65/503 - (12%)


- Green bases have known domain annotations that are detailed below.


Human   118 LEVVDILLNYVRKTFDRS-TKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGV- 180
            :|:|:.:.||:....:|. |..::..:...||..      |....||..:||:.|..|.:..|| 
  Fly    11 MEMVEYICNYLETLNERRVTPSVEPGYLRHLLPP------EAPQEPEDWDQIMRDVEDKIMPGVT 69

Human   181 RTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGW------ 239
            ...||||......|.....:.|:.|........|::..:|....:|.|.|..:.:.:|.      
  Fly    70 HWQHPRFHAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVLDWLGKAIGLPDHFLA 134

Human   240 --SSKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAA-----VPKLVLFTSEQSHYSIKKA 297
              ....|.|:.....:...:.:::|||.:....:|.:....     :.||:.:.|:::|..::||
  Fly   135 LKEGSTGGGVIQTSASECVLVTMLAARAQALKRLKAQHPFVEEGHLLSKLMAYCSKEAHSCVEKA 199

Human   298 GAALGFGTDNVILIKCNERGKIIPADFEAK-----ILEAKQ----KGYVPFYVNATAGTTVYGAF 353
            .            :.|..:.:|:..|.:|.     |.||.:    :|.|||:|:.|.|||...||
  Fly   200 A------------MICFVKLRILEPDDDASLRGQTIYEAMEEDELQGLVPFFVSTTLGTTGSCAF 252

Human   354 DPIQEIADICEKY-NLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAIL 417
            |.:.||....::: .:|||||||:.|...:..:.:..|.|||.|:|...||:|.:.....||.:.
  Fly   253 DNLPEIGKQLQRFPGVWLHVDAAYAGNSFICPELKPLLKGIEYADSFNTNPNKWLLTNFDCSTLW 317

Human   418 VKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINK 482
            |:::  ::..:.:....|:......|.:.|.....:...|.....|.|.:.::.|..|.::.|..
  Fly   318 VRDR--IRLTSALVVDPLYLKHGYSDAAIDYRHWGVPLSRRFRSLKLWFVLRSYGISGLQHYIRH 380

Human   483 CLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAPKIKALMM 547
            .::||:.....:...:.||:.  .:.:...|||     .|:|       .:||::   |:.:::.
  Fly   381 HIKLAKRFEELVLKDKRFEIC--NQVKLGLVCF-----RLKG-------SDKLNE---KLLSIIN 428

Human   548 ESGTTMVGYQPQGDKANF-FRMVISNPAATQSDIDFLIEEIERLGQDL 594
            |||...:.....||:... |..|..|  ||..|||:..:.|.....:|
  Fly   429 ESGKLHMVPASVGDRYIIRFCAVAQN--ATAEDIDYAWDIIVDFANEL 474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GAD1NP_000808.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Pyridoxal_deC 144..518 CDD:395219 93/397 (23%)
Tdc2NP_724489.1 Pyridoxal_deC 35..414 CDD:395219 93/405 (23%)
Blue background indicates that the domain is not in the aligned region.

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