Protein Alignment FRMD3 and frmd3

DIOPT Version :9

• Sequence 1: NP_777598.3
• Gene: FRMD3 / 257019
• HGNCID: 24125
• Length: 597
• Species: Homo sapiens
• Sequence 2: NP_001072510.1
• Gene: frmd3 / 779965
• XenbaseID: XB-GENE-1011845
• Length: 585
• Species: Xenopus tropicalis
• Alignment Length: 584
• Identity: 438/584 - (75%)
• Similarity: 516/584 - (88%)
• Gaps: 6/584 - (1%)

Human    17 MIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPE 81
            |:..|::|::||:.:||||||||||:|||.:|||:||||||:|:|||:|:||||||||||:||||
 Frog     1 MMRLRTASLRSLNLDMRCTIRLLDDTEISFNIQRDTKGQFLLDYICNHYNLLEKDYFGIRFVDPE 65

Human    82 KQRHWLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFS 146
            ||||||:|:|.:.||||:||||||||||||||||||||||||||||||||||||||||||||.|:
 Frog    66 KQRHWLDPSKPVAKQMKSHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCCFA 130

Human   147 DAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLL 211
            |||:|||||||||:|||||||||:|||.:|:||||||||||||||||||||||||||.|:|||||
 Frog   131 DAAFLGACIVQAEIGDYDPDEHPDNYICDFKIFPKQSQKLERKIVEIHKNELRGQSPSVSEFNLL 195

Human   212 LKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGKTFYVIGT 276
            ||||:||||||||||||||||||||||:|||||||||||||||||||||:||:||:||||:|:..
 Frog   196 LKAHSLETYGVDPHPCKDSTGTTTFLGYTAAGFVVFQGNKRIHLIKWPDICKMKFDGKTFHVVVM 260

Human   277 QKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKGSRFRYSGKVAKEV 341
            |||||.:|.:|||||||||||||||||||||||||||||:|||:||.||||||||||.|||||||
 Frog   261 QKEKKNILTYHTSTPAACKHLWKCGVENQAFYKYAKSSQVKTVTSSNIFFKGSRFRYCGKVAKEV 325

Human   342 VEASSKIQREPPEVHRANITQSRSSHSLNKQLIINMEPLQPLLPSPS----EQEEELPLGEGV-P 401
            |||||||||:||||||:.|..||||:||||||||||||||||:|||:    |:|||..:.||: .
 Frog   326 VEASSKIQRDPPEVHRSLIPHSRSSYSLNKQLIINMEPLQPLIPSPNEEEEEEEEENQIDEGILL 390

Human   402 LPKEENISAPLISSSPVKAAREYEDPPSEEEDKIKEEPLTISELVYNPSASLLPTPVDDDEIDML 466
            |.:.|..|||::.:||.:......|...:||:.|:||||||||.||||||||||||||:. ||||
 Frog   391 LQQSEASSAPVLGNSPARGLETTADVTHDEEESIREEPLTISEQVYNPSASLLPTPVDEG-IDML 454

Human   467 FDCPSRLELEREDTDSFEDLEADENAFLIAEEEELKEARRALSWSYDILTGHIRVNPLVKSFSRL 531
            |:.|.|.|.|::||||||||||||:|||||||||:||||:||||||:.:.|::::|..:||||:|
 Frog   455 FNSPLRAEREKDDTDSFEDLEADEHAFLIAEEEEMKEARKALSWSYNFIMGNMQLNAFLKSFSKL 519

Human   532 LVVGLGLLLFVFPLLLLLLESGIDLSFLCEIRQTPEFEQFHYEYYCPLKEWVAGKVHLILYMLG 595
            |:..:|||:.|.||||:||||.||:|||.|||.||||||||:|||||.::|||.|:...|.:.|
 Frog   520 LLAAIGLLMVVLPLLLILLESDIDVSFLREIRLTPEFEQFHHEYYCPFRKWVACKLSAALNLFG 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRMD3	NP_777598.3	B41	33..225	CDD:214604	165/191 (86%)
		FERM_N	36..98	CDD:286467	47/61 (77%)
		FERM_M	117..225	CDD:278785	96/107 (90%)
		PH-like	206..309	CDD:302622	88/102 (86%)
		FA	323..>357	CDD:285894	30/33 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..403		10/24 (42%)
frmd3	NP_001072510.1	B41	17..209	CDD:214604	165/191 (86%)
		FERM_N	20..83	CDD:286467	48/62 (77%)
		FERM_M	101..209	CDD:278785	96/107 (90%)
		FERM_C_FRMD3_FRMD5	190..293	CDD:270013	88/102 (86%)
		FA	307..343	CDD:285894	32/35 (91%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	284	1.000	Domainoid score	I10007
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H16012
Inparanoid	1	1.050	917	1.000	Inparanoid score	I3586
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40727
OrthoDB	1	1.010	-	-		D105082at32523
OrthoFinder	1	1.000	-	-		FOG0002996
OrthoInspector	1	1.000	-	-		oto158481
Panther	1	1.100	-	-	LDO	PTHR23280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7059
SonicParanoid	1	1.000	-	-		X1988
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110