Protein Alignment Ahr and ss

DIOPT Version :9

• Sequence 1: NP_037281.3
• Gene: Ahr / 25690
• RGDID: 2074
• Length: 853
• Species: Rattus norvegicus
• Sequence 2: NP_001163629.2
• Gene: ss / 41988
• FlyBaseID: FBgn0003513
• Length: 1015
• Species: Drosophila melanogaster
• Alignment Length: 1057
• Identity: 299/1057 - (28%)
• Similarity: 443/1057 - (41%)
• Gaps: 312/1057 - (29%)

  Rat     9 YASRKRRKPVQKTVKPVPAEGI-KSNPSKRHRDRLNTELDRLASLLPFPQDVISKLDKLSVLRLS 72
            ||:::||:. .|::||.|.:|: |||||||||:|||.|||.|||||||.|:::||||:||:||||
  Fly     8 YATKRRRRN-GKSLKPPPKDGVTKSNPSKRHRERLNAELDLLASLLPFEQNILSKLDRLSILRLS 71

  Rat    73 VSYLRAKSFFDVALKSTPADRS-----RGQDQCRAQVRDW----QDLQEGEFLLQALNGFVLVVT 128
            |||||.||:|.|.:.....|..     ...|..|  .|:.    ..|.:|:..|||||||::::|
  Fly    72 VSYLRTKSYFQVVMHKDKEDNGVLPHIHAHDGYR--TRELGAFEHGLLDGDMFLQALNGFLMILT 134

  Rat   129 ADALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHW-ALNPSQCTDSAQGVDETH 192
            .:..||:|:.:|:.||||.|||::|||||||:|:|||.|.||||.| :..|:..  |:..:.||
  Fly   135 CEGEVFFATHSIESYLGFHQSDIVHQSVYELVHSEDREELQRQLLWNSFLPADM--SSMQLAET- 196

  Rat   193 GLPQPAVYYTPDQLPPENTAFMERCFRCRLRCLLDNSSGFLAMNFQGRLKYLHGQNKKGKDGALL 257
                         |.|:...::||.|..|.||||||:||||.::.:||:|.|||||:|.::
  Fly   197 -------------LAPDKALYLERSFTVRFRCLLDNTSGFLRLDIRGRIKVLHGQNRKTEE---- 244

  Rat   258 PPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGQLILGYTEVELCNKGSGYQF 322
             |.|||||..||..|||:|||..|..:|::||||||:.:..|.:|:.||||.:.||.|.| ||..
  Fly   245 -PPLALFAYCTPFGPPSLLEIPHKENMFKSKHKLDFSLVSMDQRGKHILGYADAELVNMG-GYDL 307

  Rat   323 IHAADMLHCAESHIRMIKTGESGMTVFRLLAKHSRWRWVQSNARLIYRNGRPDYIIATQRPLTDE 387
            :|..|:.:.|.:|..::|||.|||..:|...|...|:|:|:::||:|:|.:||::|.|.|.|.||
  Fly   308 VHYDDLAYVASAHQELLKTGASGMIAYRYQKKDGEWQWLQTSSRLVYKNSKPDFVICTHRQLMDE 372

  Rat   388 EGREHLQKRSMTLPFMFA-TGKAVLY----------EISSPFSPIMDPLPIRTKSN----TSRKD 437
            ||.:.|.||:|.....:. ||.|..|          ..:||.:..:.|....|:.|    |..:|
  Fly   373 EGHDLLGKRTMDFKVSYLDTGLASTYFSEADQLVVPPSTSPTAHALPPPVTPTRPNRRYKTQLRD 437

  Rat   438 W-----------------APQSTP----------------------------------------- 444
            :                 ..|::|
  Fly   438 FLSTCRSKRKLQQQNQPQTQQTSPLGGQVGSPAPAVAVEYLPDPAAAVAAAYSNLNPMYTTSPYA 502

  Rat   445 --------------------SKDSFHPNSLMSAL------------------------------- 458
                                |::.||...|..|:
  Fly   503 SAADNLYMGSSMPANAFYPVSENLFHQYRLQGAVGGYYTDYPHSGAPASAYVANGFLSYDGYAIA 567

  Rat   459 IQQDE-------------SIYLCPPSSP------APLDSHFLMDSMSECGS------------WQ 492
            .:.||             |.|..|.|:|      .|..|..:|:.:| |.|            ..
  Fly   568 SKADEKWQETGKYYSGYSSGYGSPTSTPQQIPLKTPKSSPQVMEVIS-CSSDGPSPVGGATPNGV 631

  Rat   493 GSF-----------AAASNEALLKHEEI-----RHTQDVNLTLSGG---------PSELFP---- 528
            ||.           |||:.:...:.:.:     .|:..|.|...||         |....|
  Fly   632 GSVTPKVELAGTTAAAAAGQDPYERQTVLMWGTTHSSGVPLNSHGGRTGAGNPASPQRSTPLGNG 696

  Rat   529 ------DNKNNDL-------YSIMRNL-----GIDFEDIRSMQNEEFFRTDSSGEVDFKDIDITD 575
                  :|.||||       ::..:.|     .....:...||:::.....:|............
  Fly   697 LGYASANNNNNDLEPATAAKWNGTKELPGKSGSASTPESYQMQHDDSGLYSASSHTTSPQQQQQQ 761

  Rat   576 EILTYVQD-----SLNNSTLLNSACQQQPVSQHLSCMLQERLQLEQQ------------------ 617
            ::....:.     |..:|:|.::...||.|  |.|...|::.|.:||
  Fly   762 QLQQSQRGVGSNVSAPSSSLTSTGTDQQAV--HPSSCHQQQQQQQQQHHHAHPHPHSHHHHHHHH 824

  Rat   618 -QQLQQQHPTQTLEPQRQLCQVEVPQHELGQKTKHMQVNGM-FASWNPAPPVSFS-CPQQERKHY 679
             .:...||.::.:.......|.:..|..|.....|.|:.|: ..|..|.|||:.| .|.......
  Fly   825 HHETAHQHSSEIILTTHHQQQSQQQQQSLAGYPLHHQLVGVGSGSPPPQPPVALSRSPTTLPAVS 889

  Rat   680 SLFSG--LQGTAQEFPYKS-EVDSMPYTQNFAPCNQSLLPEHSKGTQLDFPGRDFERSLHPNASN 741
            ||.:|  ..|.|.:.||:. .:.|.|    ...|.:.:      |..:...||        .:|.
  Fly   890 SLLNGSASAGGASDIPYQQLAIVSAP----LVICAEEV------GGGVSSIGR--------KSSK 936

  Rat   742 LEDFVSCLQVPEN---QRHGINSQSAMVSPQAYYAGAMSMYQCQAGPQHTPVDQMQYSPEIPGSQ 803
            .:..:..||..::   |:|.|..|      |.:::            ||.|..|:.|...|....
  Fly   937 QQQSLQHLQQQQSLQQQQHAIYQQ------QHHHS------------QHHPHHQLLYPANITAHT 983

  Rat   804 AFLSKFQSPSILNEAYS 820
            |..   .:|.....||:
  Fly   984 ALA---YAPPTAGGAYA 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ahr	NP_037281.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38		15/29 (52%)
		HLH	36..77	CDD:238036	31/40 (78%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:P35869	37..65		20/27 (74%)
		PAS	111..>181	CDD:279347	38/70 (54%)
		PAS	111..177	CDD:214512	37/66 (56%)
		Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P30561	116..124		6/7 (86%)
		Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P30561	264..266		1/1 (100%)
		PAS	280..384	CDD:238075	44/103 (43%)
		PAS_3	295..380	CDD:285623	34/84 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	429..451		8/103 (8%)
ss	NP_001163629.2	HLH	35..76	CDD:197674	31/40 (78%)
		PAS	123..178	CDD:214512	33/54 (61%)
		PAS_3	282..366	CDD:285623	34/84 (40%)
		PAS	<291..369	CDD:238075	34/78 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341041
Domainoid	1	1.000	99	1.000	Domainoid score	I6953
eggNOG	1	0.900	-	-		E1_KOG3560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004717
OrthoInspector	1	1.000	-	-		oto96626
orthoMCL	1	0.900	-	-		OOG6_107946
Panther	1	1.100	-	-	O	PTHR10649
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3318
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.700