DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppard and Hr96

DIOPT Version :9

Sequence 1:	NP_037273.2	Gene:	Ppard / 25682	RGDID:	3370	Length:	440	Species:	Rattus norvegicus
Sequence 2:	NP_524493.1	Gene:	Hr96 / 42993	FlyBaseID:	FBgn0015240	Length:	723	Species:	Drosophila melanogaster

Alignment Length:	363	Identity:	84/363 - (23%)
Similarity:	140/363 - (38%)	Gaps:	81/363 - (22%)

- Green bases have known domain annotations that are detailed below.

  Rat    73 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLKYEKC--DRICKIQKKNRNKCQYCRFQKCLAL 135
            |.||||||.|:::....||.||.||||....|.:: .|  ::.|.|....|..||.||.:|||.:
  Fly     7 CAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQF-TCPFNQNCDITVVTRRFCQKCRLRKCLDI 70

  Rat   136 GMSHNAIRFGRMPEAE-------------KRKLVAGLT---ASEGCQQNPQLADLKAFSKHIYNA 184
            ||....|    |.|.:             ||:|:...|   .::|.::....|...:.|.::.:.
  Fly    71 GMKSENI----MSEEDKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADSSSSNLDHY 131

  Rat   185 YLKNFNMTKKKARSILTGKSSHNAPFIIHDIETLWQAEKGLVWKQLVNGPPPYNEISVHVFYRCQ 249
            .....:.:...|.|...|.|...|......:..|....:.:| .|:|:.|...:: :::...|.|
  Fly   132 SGSQDSQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKIV-DQIVSDPDRASQ-AINRLMRTQ 194

  Rat   250 STTVET--------------VRELTEFAKNIPNFSSLFLNDQVTLLKYGVHEAIFAMLAS----- 295
            ...:..              |..|.::..:.....|.|:|.....|      .:|....|
  Fly   195 KEAISVMEKVISSQKDALRLVSHLIDYPGDALKIISKFMNSPFNAL------TVFTKFMSSPTDG 253

  Rat   296 --IVNKDGLLVANGSGFVTHEFLRSIRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCG 358
              |::|   :|.:.:..|  ||::::.....|.|:...:|        ::....||.|...||.|
  Fly   254 VEIISK---IVDSPADVV--EFMQNLMHSPEDAIDIMNKF--------MNTPAEALRILNRILSG 305

  Rat   359 ----------DR-PGLMNVPQVEAI-----QDTILQAL 380
                      || |.|...|.|:..     .||::|::
  Fly   306 GGANAAQQTADRKPLLDKEPAVKPAAPAERADTVIQSM 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppard	NP_037273.2	NR_DBD_Ppar	72..155	CDD:143523	35/96 (36%)
Ppard	NP_037273.2	NR_LBD_PPAR	172..439	CDD:132730	46/246 (19%)
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	34/95 (36%)
		NR_LBD	462..>573	CDD:299703
		NR_LBD_F1	523..702	CDD:132727
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351553
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.890