Protein Alignment GABRP and Rdl

DIOPT Version :9

• Sequence 1: NP_055026.1
• Gene: GABRP / 2568
• HGNCID: 4089
• Length: 440
• Species: Homo sapiens
• Sequence 2: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Alignment Length: 534
• Identity: 142/534 - (26%)
• Similarity: 245/534 - (45%)
• Gaps: 140/534 - (26%)

Human    42 ENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFE---GNK 103
            ::.:..|:|.:|||:||.||::.:|:.:.||||:||..||:|...|.||.|.|.||.:.   |.:
  Fly    64 DSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVE 128

Human   104 SFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYP 168
            :.::.:..::.:|||||:.|..|:|:.|..|..|..||:..:|::..::|:|.|.:|.|:|..:|
  Fly   129 TLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFP 193

Human   169 MDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLV 233
            ||.|.|.:::||:||...|:.:.|..|..||.....:.|.|:.:..:....|.....||||:||.
  Fly   194 MDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQRATEINLTTGNYSRLA 258

Human   234 LQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPN 298
            .:.:..|::.|::::.|:||..:|::||||||::.::.|||..:||||||:|||||..:..:||.
  Fly   259 CEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPK 323

Human   299 TNCFIKAIDVYLGICFSFVFGALLEYAVAHY------------SSLQQMAAK-----DRGTTKEV 346
            .: ::|:||||||.||..||.:|||||...|            .::|::|.:     |....::.
  Fly   324 IS-YVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGANQQQA 387

Human   347 EEVSITNI-------------------INSSI---------------------------SSFKRK 365
            ......|:                   :|..:                           :...|.
  Fly   388 NPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRP 452

Human   366 ISFASIEISSDNVD----------YSDLTMKTSD------------------------------- 389
            |.|::|:   .||.          :.::..|..|
  Fly   453 IGFSNIQ---QNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQG 514

Human   390 ---------------------------KFKFVFREKMGRIVDYFTIQ--NPSNVDHYSKLLFPLI 425
                                       ....:...|:.::.|...:.  .||::|.||:::||:.
  Fly   515 GGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSRIVFPVC 579

Human   426 FMLANVFYWAYYMY 439
            |:..|:.||..|::
  Fly   580 FVCFNLMYWIIYLH 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRP	NP_055026.1	Neur_chan_LBD	43..437	CDD:332142	141/529 (27%)
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	62/182 (34%)
		Neur_chan_memb	274..588	CDD:397193	67/317 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4221
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.870