DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bmp3 and scw

DIOPT Version :9

Sequence 1:	NP_058801.1	Gene:	Bmp3 / 25667	RGDID:	2212	Length:	468	Species:	Rattus norvegicus
Sequence 2:	NP_001286088.1	Gene:	scw / 46000	FlyBaseID:	FBgn0005590	Length:	400	Species:	Drosophila melanogaster

Alignment Length:	440	Identity:	100/440 - (22%)
Similarity:	167/440 - (37%)	Gaps:	125/440 - (28%)

- Green bases have known domain annotations that are detailed below.

  Rat   111 LHTFNLTSLTKSENILSATLYFYIGELVNTSVNCPESQGCSHDSQRQHIQIDLSAWTLQSNQSQL 175
            |:.|.||||..:   .|||.|      |.|:               .||::.:......|.|.::
  Fly     2 LNVFFLTSLFYA---ASATTY------VTTN---------------NHIEMPIYQKRPLSEQMEM 42

  Rat   176 LGHLSVDTAKPYRDSMSWL----SKDITQLLRKAKQDEEFLIGFNITSRAHELPKRMLLFPEPYI 236
            :..|.:.. :|.|.:...|    ||.:.::..:..:|:|      .....|:..||.|   :..|
  Fly    43 IDILDLGD-RPRRQAEPNLHNSASKFLLEVYNEISEDQE------PKEVLHQRHKRSL---DDDI 97

  Rat   237 LVYAND---AAIC----------EPESVVSSLQRHRDFTAGTVPRLDSHVREAL--------SVE 280
            |:...|   .|.|          :||.:.:.|..|..|....|| :|..:.:|:        .|:
  Fly    98 LISNEDRQEIASCNSILTFSSRLKPEQLDNELDMHITFNTNDVP-VDLSLVQAMLRIYKQPSLVD 161

  Rat   281 RRKKRSTGILLPLQNNELPGAEYQYKEAGV---------WEERK---------PYKSLQTQ---- 323
            ||...:..:...|.|.:    ::.|:..|.         |.|..         ..|.||.:
  Fly   162 RRANFTVSVYRKLDNRQ----DFSYRILGSVNTTSSQRGWLEFNLTDTLRYWLHNKGLQRRNELR 222

  Rat   324 ----------------PPEKSRSKKK-----QRKGPH--QKGQTLQFDEQTLKKARR-------- 357
                            .|:.||:..:     ...||.  .|.|.|:| ::.|:|.|.
  Fly   223 ISIGDSQLSTFAAGLVTPQASRTSLEPFIVGYFNGPELLVKIQKLRF-KRDLEKRRAGGGSPPPP 286

  Rat   358 -----KQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQS 417
                 ..:..|::|.|....|||.::....|:|:||.|:||:|.|.|.||:...:..:|||.:|:
  Fly   287 PPPPVDLYRPPQSCERLNFTVDFKELHMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQT 351

  Rat   418 IVRAVGVVSGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVDSCAC 467
            ::..  ....:|:|||||..:.:::||.:.....:.|..|.......|.|
  Fly   352 LMHL--KQPHLPKPCCVPTVLGAITILRYLNEDIIDLTKYQKAVAKECGC 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bmp3	NP_058801.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..53
		TGFb_propeptide	46..>203	CDD:279078	22/95 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..93
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..349		12/59 (20%)
		TGF_beta	364..467	CDD:278448	32/102 (31%)
scw	NP_001286088.1	TGFb_propeptide	39..254	CDD:279078	42/229 (18%)
scw	NP_001286088.1	TGFB	300..400	CDD:214556	33/102 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810