DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Il1r1 and CG45263

DIOPT Version :9

Sequence 1:	NP_037255.3	Gene:	Il1r1 / 25663	RGDID:	2892	Length:	590	Species:	Rattus norvegicus
Sequence 2:	NP_731246.2	Gene:	CG45263 / 50003	FlyBaseID:	FBgn0266801	Length:	1876	Species:	Drosophila melanogaster

Alignment Length:	393	Identity:	82/393 - (20%)
Similarity:	143/393 - (36%)	Gaps:	82/393 - (20%)

- Green bases have known domain annotations that are detailed below.

  Rat     9 SAKSSILE---NMKVLLGFICLIVPLLSLETDKCTEYPNEVISFSSVNEIDIRSCPLTPNEMHGG 70
            :|||.::|   ::|.......:..|.:.||.||               :..:..|....|.  ..
  Fly   269 TAKSVVVEARLDVKYAPSIRLIGSPEIDLEEDK---------------DALVLRCVADANP--PA 316

  Rat    71 TIIWYKNDSKTPISADKDSRIHQQNEHLWFVPAKMEDSGYYYCIMRNS-------TYCLKTKITM 128
            :|:|.:...         |.|....|.|...|....|:|.|.|..:||       :..|..|...
  Fly   317 SIVWRRAGR---------SEIASLQETLQLRPVGRRDAGLYTCQAQNSVGTSEQLSVQLDVKYPP 372

  Rat   129 SVLENDPGLCYNTQASFIQRLHVAGDGSLVCPYLDFFKDENNELPKVQWYKNCKPLPLDDGNFF- 192
            .::...|           .||..|   .|..|.......:.|.||..:|.:.     :..|:.:
  Fly   373 KIISAGP-----------DRLTTA---PLFSPAAFECLADGNPLPSFKWVQR-----MAHGSKYV 418

  Rat   193 --GFKNKLMVMNVAEEHRGNYTCR-TSYTYQGKQYPVTRVITFITIDDSKRDRPVIMSPRNETME 254
              |.:::|::.||..|::|.|.|| |||....::..::..::...:...:..|   :.|...|:.
  Fly   419 ERGSESRLVIDNVTYEYQGEYECRATSYINGQERVAISDPVSLQVVGAPQVLR---LHPSLHTVS 480

  Rat   255 ADPG---STIQLICNVTGQFTDLVYWKWNGSEIEWD---DPILAEDYQFLEHPSAKRKYTLITTL 313
            ...|   |...::|  .......|.|:|....:|..   |...|:|.|    |.. |:...::||
  Fly   481 VKRGEAASLTMVVC--ADPRPQRVAWEWGSLRLEAGSGIDRFRADDMQ----PDT-REDCYLSTL 538

  Rat   314 NVSEVKSQFYRYPFICFVKNTHILETAHVRLV----YPVPDFKNYLIG--GFAIFTATAVFCACI 372
            ::........| |:...|:|....:...:.|:    :..|...:||:|  |..:.....:.|.||
  Fly   539 HILHADEHDSR-PYYLVVENERGTDRHAIHLIVEGTFAEPYEMSYLMGVAGGCMAAILLLVCLCI 602

  Rat   373 YKV 375
            |.:
  Fly   603 YAI 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Il1r1	NP_037255.3	Ig	47..130	CDD:299845	17/89 (19%)
		Ig2_IL1R_like	144..236	CDD:143234	22/95 (23%)
		Ig_3	242..333	CDD:290638	21/96 (22%)
		IG_like	251..344	CDD:214653	20/98 (20%)
		TIR	401..556	CDD:214587
CG45263	NP_731246.2	I-set	53..149	CDD:254352
		Ig	198..281	CDD:299845	4/11 (36%)
		IG_like	302..368	CDD:214653	16/76 (21%)
		IGc2	302..357	CDD:197706	15/65 (23%)
		Ig	372..446	CDD:299845	21/92 (23%)
		Ig	475..568	CDD:299845	20/100 (20%)
		IG_like	478..570	CDD:214653	21/99 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910