Protein Alignment GABRG2 and pHCl-2

DIOPT Version :10

• Sequence 1: NP_944493.2
• Gene: GABRG2 / 2566
• HGNCID: 4087
• Length: 515
• Species: Homo sapiens
• Sequence 2: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Alignment Length: 571
• Identity: 131/571 - (22%)
• Similarity: 223/571 - (39%)
• Gaps: 138/571 - (24%)

Human    24 TVWILLLLSLYPGFTSQKS---DDDYEDYASNKTWVLTPKVPEGDVTVILN-------------- 71
            |:.|.:|:| |.|.:|...   .|..::.|:|.:.|::|.......:|.:|
  Fly     3 TLGIFVLIS-YLGLSSAAGVHLGDLQQNLAANGSVVVSPLNTTDAFSVSINLSQSTVNNCPSLKN 66

Human    72 ----NLLE---------GYDNKLRPDIGVK-----PTLIHTDMYVNSIGPVNAINMEYTIDIFFA 118
                .|:|         .||..:.|.:..|     |..|:...|:..:..:::.::::|:.....
  Fly    67 AESMALMELLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLDSSDLQFTVQGLLQ 131

Human   119 QTWYDRRLKFNSTIKVLRL----NSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVL 179
            ..:.|.||.|:|.:...|.    .|.:...:|:|..|..|.:.:.....:..:.:..|:.:|.||
  Fly   132 LRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVL 196

Human   180 YTLRLTIDAECQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLAS 244
            .:.||.....|.:....||.||..|.....||..:       :.::..|:      .||.|
  Fly   197 TSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYN-------TTLVQLHW------ETDNP---- 244

Human   245 RVAGISDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVG-LRNTTEVVKTTS--------GDYV 300
                                    |...:..:|.:::.:| |.|.:..|...|        |:|.
  Fly   245 ------------------------VSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYS 285

Human   301 VMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKS 365
            ::|....|:|.:||:.|..::|..:||.:||||||:..|..||||:||.||:|:..|||.....:
  Fly   286 IISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENN 350

Human   366 LPKVSYVTAMDLFVSVCFIFVFSALVEYG-----------------TLHY-----FVSNRKPSKD 408
            |.||||||..:::..||.||:|.:|||:.                 |..|     ||.:.|..:.
  Fly   351 LMKVSYVTMSEVWFLVCTIFIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRR 415

Human   409 KDKKKKNPLLRMFSFKAPTIDIRPRSATIQM-------------NNATHLQERDEEYGYECLDG- 459
            ...::.:..:...|..:......|.:..|.:             ::|..|.|:||....|..|.
  Fly   416 HGYRRTDSTMSTMSTTSMDKTCGPNNTVITIETPIIIGGSLSREDSAISLDEQDETSTSESSDSS 480

Human   460 -KDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYW 509
             :..|..|..........|           :|...|..||.:|.:||.::|
  Fly   481 KEKPAQTFATMTPKEVSLW-----------IDRKMRFVFPLSFIVFNALFW 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRG2	NP_944493.2	LIC	69..512	CDD:455710	118/523 (23%)
		LGIC_ECD_GABAAR_G	90..311	CDD:349801	43/233 (18%)
		Cys-loop	190..204	CDD:349801	5/13 (38%)
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	119/527 (23%)