Protein Alignment GABRG2 and nAChRbeta2

DIOPT Version :10

• Sequence 1: NP_944493.2
• Gene: GABRG2 / 2566
• HGNCID: 4087
• Length: 515
• Species: Homo sapiens
• Sequence 2: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Alignment Length: 446
• Identity: 86/446 - (19%)
• Similarity: 179/446 - (40%)
• Gaps: 97/446 - (21%)

Human    65 DVTVILNNLLEGYDNKLRPDIGVKPTL-IHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKF 128
            |...:.::||..|:..:||.:....|| :...:.::.:..||..|...|.:::..|.|:|.:|::
  Fly    29 DTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRW 93

Human   129 N----STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189
            :    ..::.|.:.|.   .||:||....|:  .|.::..|......:...|.|.:.......:.
  Fly    94 DPEEYGGVEQLYVPSE---HIWVPDIVLYNN--WDGNYEVTLMTKATLKYTGEVFWEPPAIYKSS 153

Human   190 CQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYP 254
            |::.:..||.||..|.::|.||:.:.||.           .|:.........|......:::.|
  Fly   154 CEMNVEYFPYDEQICFMKFGSWTYNGAQV-----------DLKHLDQIPGSNLVQVGIDLTEFY- 206

Human   255 REEIVYQWKRSSVEVGDTRSWRLY-----QFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGY 314
               :..:|  ..:||..|::...|     .||.:..:.|                   :.|:..:
  Fly   207 ---LSVEW--DILEVPATKNEEYYPDTLEPFSDITFKLT-------------------MRRKTLF 247

Human   315 FTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVS--------- 370
            :|:...:||..:..|:.:.|::..|: ..:.:|.|:.::::|....:..:.:|..|
  Fly   248 YTVNLIVPCVALTFLTVLVFYLPSDS-GEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKY 311

Human   371 -----YVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLR-MFSFKAPTID 429
                 .:.::.::.:||.:          .:|:    |.||    ....:||:| :|      :.
  Fly   312 LLFTMILVSLSVWTTVCVL----------NIHF----RSPS----THNMSPLVRKLF------LH 352

Human   430 IRPRSATIQMNNATHLQERDE---EYGY-ECLDGKDCASFFCC-FEDCRTGAWRHG 480
            ..|:...::....| |.:.|:   ..|| ..:|.:|..|.|.. |:|.:.||:.:|
  Fly   353 FMPKLMMMRRTQYT-LPDYDDSTPSNGYTNEIDVRDSISDFPSEFKDSQDGAYDNG 407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRG2	NP_944493.2	LIC	69..512	CDD:455710	85/442 (19%)
		LGIC_ECD_GABAAR_G	90..311	CDD:349801	43/230 (19%)
		Cys-loop	190..204	CDD:349801	5/13 (38%)
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	86/446 (19%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	50/258 (19%)
		Cys-loop	154..168	CDD:349832	5/13 (38%)