Protein Alignment GABRG2 and HisCl1

DIOPT Version :10

• Sequence 1: NP_944493.2
• Gene: GABRG2 / 2566
• HGNCID: 4087
• Length: 515
• Species: Homo sapiens
• Sequence 2: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Alignment Length: 444
• Identity: 127/444 - (28%)
• Similarity: 215/444 - (48%)
• Gaps: 91/444 - (20%)

Human    77 YDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKF--NSTIKVLRLNS 139
            ||....|.:..:||:::..:.|.|:..:|..:|.|..|||.||:|.|.||:.  |.:.:...|:.
  Fly    67 YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDV 131

Human   140 NMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSC 204
            :.:..||.||.||:|:||...|.::.||..|.:::|..:||..:||:...|.::..::|.|...|
  Fly   132 DWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQIC 196

Human   205 PLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRV----AGISDGYPREEIVYQWKRS 265
            .:...|.|.::...            :..|..|||..:.:.:    ..||:.|
  Fly   197 SMMIESLSHTVEDL------------VFIWNMTDPLVVNTEIELPQLDISNNY------------ 237

Human   266 SVEVGDTRSWRLYQFSFVGLRNTTE-VVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVL 329
                                  ||: .::.::|::..:::.|:|.||:||....||||..||||:
  Fly   238 ----------------------TTDCTIEYSTGNFTCLAIVFNLRRRLGYHLFHTYIPSALIVVM 280

Human   330 SWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYG 394
            ||:||||..:|:|||.:||:|::||:.|.:|.:::|||.||||.|:|:::|.|.:|||.:|:|:.
  Fly   281 SWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSYVKAIDVWMSSCSVFVFLSLMEFA 345

Human   395 TLHYFVSNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDG 459
            .::.|:........|....:|           ..|:....:.:|     |.:|...|..|:.
  Fly   346 VVNNFMGPVATKAMKGYSDEN-----------ISDLDDLKSALQ-----HHRESIIEPQYDT--- 391

Human   460 KDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYL 513
                  ||           ||  |.....:|.::|.|||.:|.:.|:|||.::|
  Fly   392 ------FC-----------HG--HATAIYIDKFSRFFFPFSFFILNIVYWTTFL 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRG2	NP_944493.2	LIC	69..512	CDD:455710	126/441 (29%)
		LGIC_ECD_GABAAR_G	90..311	CDD:349801	53/227 (23%)
		Cys-loop	190..204	CDD:349801	3/13 (23%)
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	54/229 (24%)
		Cys-loop	182..196	CDD:349793	3/13 (23%)
		LGIC_TM_anion	265..>351	CDD:349851	42/85 (49%)
		TM1 helix	265..288	CDD:349851	14/22 (64%)
		TM2 helix	292..316	CDD:349851	10/23 (43%)
		TM3 helix	324..350	CDD:349851	9/25 (36%)