Protein Alignment GABRG2 and SecCl

DIOPT Version :10

• Sequence 1: NP_944493.2
• Gene: GABRG2 / 2566
• HGNCID: 4087
• Length: 515
• Species: Homo sapiens
• Sequence 2: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Alignment Length: 582
• Identity: 117/582 - (20%)
• Similarity: 215/582 - (36%)
• Gaps: 176/582 - (30%)

Human    26 WI--LLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDV--TVILNNLLE--GYDNKLRP- 83
            ||  :|:||::.....:..:::....|.           .|.:  |.::..|..  .||...||
  Fly    11 WITLILVLSIWTSVGVKAEEEECPSMAD-----------AGSLQQTQLIQRLTHVCRYDRLERPF 64

Human    84 --DIGVK--PTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVG- 143
              |...|  |.::.|.:||..:..:|:..:::.:.......:.|:||.:    |....:.|::|
  Fly    65 EYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAY----KAFNRSDNILGQ 125

Human   144 -----KIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHS 203
                 ::|:|..||.|.:::........:.:..:..:|.|:.:.|:.....|.:....||.|:..
  Fly   126 KHLSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQF 190

Human   204 CPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYPREEIVYQWKRSSVE 268
            |.....||.                                        |...:::.:|: ....
  Fly   191 CSTVLESWM----------------------------------------YNTSDLILEWE-PHTP 214

Human   269 VGDTRSWRLYQFSFVGLRNTTEVVKTT---------SGDYVVMSVYFDLSRRMGYFTIQTYIPCT 324
            :......||.:::.....:.|.:|::.         :|:|..:|...:|.|.:|::.:..|:|..
  Fly   215 ISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSM 279

Human   325 LIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSA 389
            :||.:||||||:..||.|.|..||.:|:|:..|||:...|:||||||:...:::...|..|:|.:
  Fly   280 MIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVSYIKVSEVWFLGCTFFIFGS 344

Human   390 LVEYGTLHYFVSNRKPSKDK-DKKKKN-------------------------------------- 415
            |||:.    ||:.....|:. :.||.|
  Fly   345 LVEFA----FVNTIWRRKENIELKKVNSKYIIKSTLTPRPARRQIGGSLSNESRARSCSSLDNIV 405

Human   416 ---------------------------PLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYG 453
                                       |::|....:|.|:.|    .:.:.|| .|:.:.|:
  Fly   406 SSTESVRNGNGTVNQGFNNYLTVHPNLPIIRTECAEADTVSI----CSARTNN-DHIVDVDK--- 462

Human   454 YECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 515
                |.||....|..........|           :|..:|..||..|..||.:|| :::|:
  Fly   463 ----DKKDTPPTFTTMTPQEIAMW-----------IDRRSRFLFPAMFLAFNALYW-TFVYV 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRG2	NP_944493.2	LIC	69..512	CDD:455710	108/530 (20%)
		LGIC_ECD_GABAAR_G	90..311	CDD:349801	35/235 (15%)
		Cys-loop	190..204	CDD:349801	4/13 (31%)
SecCl	NP_648984.2	LIC	43..505	CDD:455710	109/534 (20%)