Protein Alignment GABRG2 and Rdl

DIOPT Version :10

• Sequence 1: NP_944493.2
• Gene: GABRG2 / 2566
• HGNCID: 4087
• Length: 515
• Species: Homo sapiens
• Sequence 2: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Alignment Length: 644
• Identity: 164/644 - (25%)
• Similarity: 255/644 - (39%)
• Gaps: 211/644 - (32%)

Human    16 TPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTV--ILNNLLEGYD 78
            ||:    :|:|:.:.::|....|..|.....:......:.:       |||.:  ||::....||
  Fly    18 TPL----LTIWLAINMALIAQETGHKRIHTVQAATGGGSML-------GDVNISAILDSFSVSYD 71

Human    79 NKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNST--IKVLRLNSNM 141
            .::||:.|..|..:...|||.||..::.:.|::|:|.:|.|.|.|.||.:...  ::.|.:.|..
  Fly    72 KRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGSEF 136

Human   142 VGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPL 206
            :..||:|||||.|.|::..|..||.|..:|:.:.|.:..::||||.|.|.:.|..||||...|.:
  Fly   137 IKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLCHI 201

Human   207 EFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYPREEIVYQWKRSSVEVGD 271
            |..|:                                        ||...:|.|.|:.....||.
  Fly   202 EIESF----------------------------------------GYTMRDIRYFWRDGLSSVGM 226

Human   272 TRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWI 336
            :....|.||..:|.|.....:..|:|:|..::......|.|||:.||.|||..|||::||||||:
  Fly   227 SSEVELPQFRVLGHRQRATEINLTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWL 291

Human   337 NKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVS 401
            |::|.|||.:||:|||||||||.:....:|||:|||.::|:::..||:.||::|:||.|:.|...
  Fly   292 NRNATPARVALGVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAK 356

Human   402 NRKPSKDK--------DKKKK------------NPLLRM-------------------------- 420
            ..:..|.:        ::||:            ||...:
  Fly   357 RIQMRKQRFMAIQKIAEQKKQQLDGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGM 421

Human   421 --------------FSFKAP-----TIDIRPRS-ATIQMNNATHLQERDEEYGYECLDGKDCASF 465
                          .|...|     |:..||.. :.||.|..|                :.|:..
  Fly   422 GMGPEHGHGHGHHAHSHGHPHAPKQTVSNRPIGFSNIQQNVGT----------------RGCSIV 470

Human   466 FCCFEDC-----------------------RTGAWRHG--------------------------- 480
            ...|::.                       |.|...||
  Fly   471 GPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGG 535

Human   481 ---------RIH---------------IRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 515
                     .:|               |..:.:|.|:||.||..|..|||:||:.||::
  Fly   536 DPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSRIVFPVCFVCFNLMYWIIYLHV 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRG2	NP_944493.2	LIC	69..512	CDD:455710	152/584 (26%)
		LGIC_ECD_GABAAR_G	90..311	CDD:349801	60/222 (27%)
		Cys-loop	190..204	CDD:349801	6/13 (46%)
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	60/222 (27%)
		Cys-loop	185..199	CDD:349809	6/13 (46%)
		Neur_chan_memb	274..588	CDD:460753	76/329 (23%)