Protein Alignment GABRG2 and nAChRbeta1

DIOPT Version :10

• Sequence 1: NP_944493.2
• Gene: GABRG2 / 2566
• HGNCID: 4087
• Length: 515
• Species: Homo sapiens
• Sequence 2: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 423
• Identity: 84/423 - (19%)
• Similarity: 163/423 - (38%)
• Gaps: 111/423 - (26%)

Human    26 WILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRP------D 84
            |:|..:.:...|:...:.:|.|.                    ::.:|..||:..:||      .
  Fly     8 WLLCSILVLVAFSLVSASEDEER--------------------LVRDLFRGYNKLIRPVQNMTQK 52

Human    85 IGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNST----IKVLRLNSNMVGKI 145
            :||:..|....: :|    ||..|.....:::....|||.:|:::..    |.||||..:   |:
  Fly    53 VGVRFGLAFVQL-IN----VNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPD---KV 109

Human   146 WIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSS 210
            |.||....|:  ||.::.......:.|:..|.||:.......:.|.:.:..||.|:.:|.::|.|
  Fly   110 WKPDIVLFNN--ADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGS 172

Human   211 WSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYPREEIVYQWKRSSVEVGDTRSW 275
            |:.:..|.           ||..:.:       .....:||         .||..:.::.:..::
  Fly   173 WTFNGDQV-----------SLALYNN-------KNFVDLSD---------YWKSGTWDIIEVPAY 210

Human   276 -RLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKD 339
             .:|:    |..|     ..|..|   ::.|..:.|:..::|:...:|..||..|..:.|::..:
  Fly   211 LNVYE----GDSN-----HPTETD---ITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAE 263

Human   340 AVPARTSLGITTVLTMTTLSTIARKSLPKVSYV--------------TAMDLFVSVCFI------ 384
            | ..:.:|||:.:|::.....:..|.||..|.|              ..:.:.|:|..|
  Fly   264 A-GEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRG 327

Human   385 --------FVFSALVEYGTLHYFVSNRKPSKDK 409
                    ::.|..:.|  |..|:..::|.|.:
  Fly   328 PRTHRMPMYIRSIFLHY--LPAFLFMKRPRKTR 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRG2	NP_944493.2	LIC	69..512	CDD:455710	79/380 (21%)
		LGIC_ECD_GABAAR_G	90..311	CDD:349801	46/225 (20%)
		Cys-loop	190..204	CDD:349801	4/13 (31%)
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	84/423 (20%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	56/277 (20%)
		Cys-loop	152..166	CDD:349833	4/13 (31%)