Protein Alignment GABRG2 and alka

DIOPT Version :10

• Sequence 1: NP_944493.2
• Gene: GABRG2 / 2566
• HGNCID: 4087
• Length: 515
• Species: Homo sapiens
• Sequence 2: NP_610619.2
• Gene: alka / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Alignment Length: 519
• Identity: 126/519 - (24%)
• Similarity: 216/519 - (41%)
• Gaps: 105/519 - (20%)

Human    14 YSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYD 78
            ::|..|......:||:.||        ::.:.:.:|.:....||.|                .|.
  Fly     5 FNTNAFISFGLGFILMWLS--------EATEAHMNYTAKPRVVLPP----------------NYV 45

Human    79 NKLRPDIGV-KPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLK-----FNSTIKVLRL 137
            .::||.... .|.::...::|..|..:|..:|::.:|:|..|.|.:.||:     |......:.|
  Fly    46 KEIRPPSKKGSPVIVDFSIFVVDINSINVEDMDFRVDMFIHQRWLESRLEIPDDIFEEGDDYVTL 110

Human   138 NSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEH 202
            ...:....|.||.:|.|||.|:...:|.....:.::.:..|.|..|:.....||::...:|||..
  Fly   111 LPEVFENFWQPDPYFLNSKIAEIATLTHKFTSVTLYKNKTVRYAARMHAIIACQMEFQLYPMDIQ 175

Human   203 SCPL---EFSSWSRSIAQAGMCSGV-ISAHYSLRFWGSTDPPTLASRVAGISDGYPREEIVYQWK 263
            .||:   .|||.::.:......||| ::....|..:....|..|..     ||||..|::
  Fly   176 VCPIYIESFSSNNQKVKLRWSDSGVTLNPELKLLQYNLGQPLELEE-----SDGYMPEKV----- 230

Human   264 RSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVV 328
                                             |::..::|||...|::|:..|||:.|.:|:|:
  Fly   231 ---------------------------------GNFSRLTVYFRFERQIGHHLIQTFAPSSLVVM 262

Human   329 LSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEY 393
            |||.|||:..||:|.|.:|.:|.:||:.|:.|.|  .:|.|:||.|:||:::.|.:.||:||.|:
  Fly   263 LSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFTGA--DIPPVAYVKALDLWMAGCMLSVFAALAEF 325

Human   394 GTL------HYFVSNRKPS---KDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERD 449
            ..:      :.:..||.|.   ......:|.....:.|::...:..|..:.|......|.||..
  Fly   326 VVVKVLDVQYQYQVNRIPKVLPMRISNMEKGQCATVASWEGGAVRSRKATQTPTTPGQTSLQGN- 389

Human   450 EEYGYECLDGKDCASFFCCFEDCRTGA----WRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYW 509
               |......:..:.....:.|..||.    ||         ::|..:|..||..|.:|.|:||
  Fly   390 ---GGPPKPARRQSLLSVAWTDTDTGVEKIMWR---------EIDKVSRAVFPILFFVFVLLYW 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRG2	NP_944493.2	LIC	69..512	CDD:455710	116/464 (25%)
		LGIC_ECD_GABAAR_G	90..311	CDD:349801	49/229 (21%)
		Cys-loop	190..204	CDD:349801	5/13 (38%)
alka	NP_610619.2	LIC	8..441	CDD:455710	123/514 (24%)