Protein Alignment GABRG2 and CG6927

DIOPT Version :10

• Sequence 1: NP_944493.2
• Gene: GABRG2 / 2566
• HGNCID: 4087
• Length: 515
• Species: Homo sapiens
• Sequence 2: NP_572194.1
• Gene: CG6927 / 31419
• FlyBaseID: FBgn0029733
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 587
• Identity: 133/587 - (22%)
• Similarity: 215/587 - (36%)
• Gaps: 173/587 - (29%)

Human    28 LLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGD---VTVILNNLLEG--YDNKLRP---- 83
            :||..||.  ::...|:|            .|.:.:||   .|.:|:.|..|  ||...||
  Fly     9 ILLNCLYA--SASALDED------------CPTLDDGDSLSQTQLLDRLTHGCRYDRLERPITYS 59

Human    84 DIGVK-PTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRL----NSNMVG 143
            :.|.: |..::...|:..:..:.|.::::.|.......:.|.||.|.:.....|.    ..::..
  Fly    60 ETGQRLPVDVYMRAYIYFMQNLEAHDLQFKIYALLQMRYLDPRLNFRNVSPKRRQPILGEEHLRN 124

Human   144 KIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEF 208
            .:|:|..|..|.:.:....:|..:.:..|..||.|:.:.|:.....|.|.|..||.||..|....
  Fly   125 SLWMPHIFLANERDSSILGLTEKDILTSISPDGTVIVSNRIKATLYCWLNLKKFPFDEQHCSTVL 189

Human   209 SSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDG-YPREEIVYQ--WKRSSVEVG 270
            .||..:.::       :..|     |....|.|.        || ....|.|.|  |...:|...
  Fly   190 ESWMYNTSE-------LVLH-----WEQKRPITY--------DGALHLTEFVLQRSWSNETVINA 234

Human   271 DTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFW 335
            |....|...|               :|:|..:|....|:|.:|::.:..::|..|||.:||||||
  Fly   235 DLSDLRHGAF---------------AGNYSSLSFTVHLTRVVGFYLMDYFLPSMLIVAISWVSFW 284

Human   336 INKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV 400
            :..|..|.|.:||.:|:||..||::...|:||||||:...:::...|.||:|.::||:..::...
  Fly   285 LQADQAPPRITLGTSTLLTFITLASAQGKTLPKVSYIKVSEVWFLGCTIFIFGSMVEFAFVNTIW 349

Human   401 SNRK--PSKDKDKK--------------KKNPLLRMFSFKA-----------------------P 426
            ..:|  |.|..:.|              :.:...|.||..|                       |
  Fly   350 RRKKSVPVKKLNSKHILKSTLSPNLLRRRSHARSRSFSGTALHKTADTGSLGGAGFNNYLTVNLP 414

Human   427 TIDIR-----------------------------------------PRSATIQMNNATHLQERDE 450
            ...|:                                         ..|.|:..||.|......|
  Fly   415 ITTIKEGQVLDQQRTSRVVQKMDVNFVESAFGSMGSAQSTGAISAASSSQTLTNNNRTESAGHQE 479

Human   451 EY---GYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSY 512
            |.   |:..|..::.|            .|           :||.||..||.:|.:|||.:| ::
  Fly   480 EIDLSGWTTLTPQEIA------------MW-----------IDSRARFVFPLSFLVFNLFFW-TF 520

Human   513 LY 514
            :|
  Fly   521 VY 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRG2	NP_944493.2	LIC	69..512	CDD:455710	122/539 (23%)
		LGIC_ECD_GABAAR_G	90..311	CDD:349801	46/227 (20%)
		Cys-loop	190..204	CDD:349801	7/13 (54%)
CG6927	NP_572194.1	LIC	3..520	CDD:455710	132/583 (23%)