Protein Alignment MFSD8 and SIT1

DIOPT Version :10

• Sequence 1: NP_001358520.1
• Gene: MFSD8 / 256471
• HGNCID: 28486
• Length: 521
• Species: Homo sapiens
• Sequence 2: NP_010849.3
• Gene: SIT1 / 856644
• SGDID: S000000791
• Length: 628
• Species: Saccharomyces cerevisiae
• Alignment Length: 503
• Identity: 88/503 - (17%)
• Similarity: 168/503 - (33%)
• Gaps: 186/503 - (36%)

Human    63 YLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYAYLHIP 127
            |::.|||....      |..|:  :|...||:         :..|..|:.:     ..|||
Yeast    46 YIELIDPGVHN------IEIYA--EMYNRPIY---------RVALFFSLFL-----IAYAY---- 84

Human   128 ASHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPVFQTCFTF 192
                        ||    .||:..  ::.|.|||...:.|.::.::..:.:...:|.:|   |..
Yeast    85 ------------GL----DGNIRY--TFQAYATSSYSQHSLLSTVNCIKTVIAAVGQIF---FAR 128

Human   193 LGEKGVTWDVIKLQINMYTTPVLLSA---------------FLGILNIILILAILREHRVDDSGR 242
            |.:....:.::.:.|..|:...::.:               .||:..|||||.::        ..
Yeast   129 LSDIFGRFSIMIVSIIFYSMGTIIESQAVNITRFAVGGCFYQLGLTGIILILEVI--------AS 185

Human   243 QCKSINFEEASTDEAQVP-------QGNIDQVAVVAINVLFFVTLFIFAL--------------- 285
            ...::|:...:.....:|       .||:  .:.:..|..:.:.::.|.|
Yeast   186 DFSNLNWRLLALFIPALPFIINTWISGNV--TSAIDANWKWGIGMWAFILPLACIPLGICMLHMR 248

Human   286 --------------FETI----ITPLTMDMYAWTQEQAVLYNGIILAALGVEAVVIFLGVKLLSK 332
                          ||.:    .....:|:..|.           |..:|:..:.:|.|..|:.
Yeast   249 YLARKHAKDRLKPEFEALNKLKWKSFCIDIAFWK-----------LDIIGMLLITVFFGCVLVP- 301

Human   333 KIGERAILLGGLIVVW----------VGFFILLP----WG---NQFPKIQWEDLHNNSIPNTTFG 380
                 ..|.|||...|          :|:.::||    |.   ::.|...|:.:.:..|    |.
Yeast   302 -----FTLAGGLKEEWKTAHIIVPEVIGWVVVLPLYMLWEIKYSRHPLTPWDLIQDRGI----FF 357

Human   381 EIIIGL-----WKSPMEDDNERPTGCSIEQAWCLYTP-VIHLAQFLTSAVLIGLGYPVCNLMSYT 439
            .::|..     |.  |:.|             .:||. |:.:.:.:.||..|...|...:::..|
Yeast   358 ALLIAFFINFNWY--MQGD-------------YMYTVLVVAVHESIKSATRITSLYSFVSVIVGT 407

Human   440 LYS----KILGPKPQVSQGVYMGWLTASG--------SGAR--ILGPM 473
            :..    |:...||.:..|:.. |:.:.|        |||.  |:|.:
Yeast   408 ILGFILIKVRRTKPFIIFGISC-WIVSFGLLVHYRGDSGAHSGIIGSL 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MFSD8	NP_001358520.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Dileucine internalization motif. /evidence=ECO:0000269|PubMed:34910516	13..14
		MFS_MFSD8	39..510	CDD:340884	88/503 (17%)
SIT1	NP_010849.3	MFS_ARN_like	70..582	CDD:340880	79/462 (17%)