DRSC/TRiP Functional Genomics Resources

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Protein Alignment MFSD8 and AMF1

DIOPT Version :10

Sequence 1:NP_001358520.1 Gene:MFSD8 / 256471 HGNCID:28486 Length:521 Species:Homo sapiens
Sequence 2:NP_015023.1 Gene:AMF1 / 854560 SGDID:S000005905 Length:515 Species:Saccharomyces cerevisiae


Alignment Length:586 Identity:109/586 - (18%)
Similarity:182/586 - (31%) Gaps:241/586 - (41%)


- Green bases have known domain annotations that are detailed below.


Human    22 EWDILETEEHYKS-RWRS--IRILYLTMFLSSVGFSVVMMSIWPYLQKIDP---------TADTS 74
            |:||  .:|..|| .|.|  :.:|.....::..|..          |.:.|         |.:..
Yeast    28 EFDI--QDERPKSLLWESAFVGVLCSAQLMTQAGLG----------QSLAPLHIIGNSFGTTNAG 80

Human    75 FLGWVIASYSL--GQMV-----ASPIFG-------------LWS--------------------- 98
            .|.|..::|||  |..:     ...|||             |||                     
Yeast    81 QLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFDCCRAFQ 145

Human    99 -----------------NYRP-RKEPLIVSI----------LISVAANCL-------YAYLHIPA 128
                             .|:| |::.::.|:          |.:|.::.|       :||     
Yeast   146 GMGPAFLLPNAIAILGRTYKPGRRKNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAY----- 205

Human   129 SHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQER-TSSMANISMCQALGFILGPVFQTCFTF 192
                       .::||....:||...:....|.:..| .||...:......|.:.|.|....|.|
Yeast   206 -----------WIMGIACFVLAVAGYFVIPHTPMPSRDASSFKLLERIDFAGSVTGVVGLILFNF 259

Human   193 LGEKG--VTWDVIKLQINMYTTPVLLSAFLGILNIILILAILREHRVDDSGRQCKSINFEEASTD 255
            ...:|  |.|.      ..||..:|:   :|...:::...|       :|......:.|...|:|
Yeast   260 AWNQGPVVGWQ------TPYTYALLI---VGTFFLVIFAYI-------ESRAAFPLLPFAALSSD 308

Human   256 EAQVPQGNIDQVAVVAINVLFFVTLFIFALFETI--------------ITPLTMDMYAWTQEQAV 306
            .|.|       ::.:|.....| .::||..::.:              .:|:.:..:.     |.
Yeast   309 TAFV-------LSCIAAGWASF-GIWIFYTWQFMEDSRGQTPLLSSAQFSPVAISGFC-----AA 360

Human   307 LYNGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVV--------WVGFF---ILLPWGNQ 360
            :..|.:|:......|::|          ...|..:|.:::.        |...|   |::|||..
Yeast   361 VTTGFLLSHTPPSTVMLF----------AMTAFTVGTILIATAPVHQTYWAQTFVSIIVMPWGMD 415

Human   361 FPKIQWEDLHNNSIPNTTFGEIIIGLWKSPMEDDNERPTGCSIEQAWCLYTPVIH--LAQFLTSA 423
            .           |.|..|.           |..|:               .|..|  ||..|.:.
Yeast   416 M-----------SFPAATI-----------MLSDS---------------MPHEHQGLAASLVNT 443

Human   424 VL-----IGLGYPVCNLMSYTLYSKIL--GPKPQVSQGVYMGWLTASGSGARILGPMFISQVYAH 481
            |:     ||||      ::.|:.|::.  |.||  .:|....|.  .|.|...|| :|::..|| 
Yeast   444 VVNYSISIGLG------IAGTIESRVNDGGAKP--LKGYRCSWY--MGIGLSGLG-IFVAATYA- 496

Human   482 W 482
            |
Yeast   497 W 497

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MFSD8NP_001358520.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Dileucine internalization motif. /evidence=ECO:0000269|PubMed:34910516 13..14
MFS_MFSD8 39..510 CDD:340884 101/566 (18%)
AMF1NP_015023.1 MFS_Amf1_MDR_like 48..493 CDD:341029 98/557 (18%)
Blue background indicates that the domain is not in the aligned region.

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