DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a23-3a1 and Cyp6a22

DIOPT Version :9

Sequence 1:	NP_037237.2	Gene:	Cyp3a23-3a1 / 25642	RGDID:	628626	Length:	502	Species:	Rattus norvegicus
Sequence 2:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	151/514 - (29%)
Similarity:	247/514 - (48%)	Gaps:	54/514 - (10%)

- Green bases have known domain annotations that are detailed below.

  Rat     9 LETWVLLAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPF-FGTVLNYYMGLWKFDV--ECHKKY-- 68
            |:...||.:.|.:.:.|....:..:.::|| |.:|..| .|.:..:.......|:  ..::|:
  Fly     2 LDVVALLLIALAVGFWFVRTRYSYWTRRGI-GSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKG 65

  Rat    69 --GKIWGLFDGQMPLFAITDTEMIKNVLVK-----ECFSVFTNRRDFGPVGIMGKAISVSKDEEW 126
              ....|.|....|:..:||.|:.|.:|::     |...::.|.||....|.:.:.    ...:|
  Fly    66 NGAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFRI----DGPKW 126

  Rat   127 KRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQEKGKP----VPVKEVFGAYSMDVITSTSF 187
            :..|..:||||||.::|.|||.:.:.|:.|.:...:.....    :.:.::...|:.|||...:|
  Fly   127 RPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVIGRCAF 191

  Rat   188 GVNVDSLNNPKDPFVEKAKKLLR-------IDFFDPLFLSVVLFPFLTPVYEMLNICMFPKDSIE 245
            ||..:.|.||:..|....::...       :|.|...|..|..|         |.:....:|..:
  Fly   192 GVECNGLRNPEAEFAIMGRRAFSERRHCKLVDGFIESFPEVARF---------LRMRQIHQDITD 247

  Rat   246 FFKKFVYRMKETRLDSVQKH--RVDFLQLMMNAHNDSKDKESHTALSDMEITAQSIIFIFAGYEP 308
            |:...|   :||.....::.  |.||:.|::       :.:....|:..|:.||:.||..||::.
  Fly   248 FYVGIV---RETVKQREEQGIVRSDFMNLLI-------EMKQRGELTIEEMAAQAFIFFAAGFDT 302

  Rat   309 TSSTLSFVLHSLATHPDTQKKLQEEIDRALP-NKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRL 372
            ::|||.|.|:.||..|..|.||:||||:||. :....|||::.|:.|:::|:.||||.|||..:|
  Fly   303 SASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKYPILPQL 367

  Rat   373 ERVCKKDVEING---VFMPKGSVVMIPSYALHRDPQHWPEPEEFRPERFSKENKGSIDPYVYLPF 434
            .|:.:......|   .::..|.:::||.|.:|.||..:|||.:|.||||..:.........:|||
  Fly   368 TRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAAWLPF 432

  Rat   435 GNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQG-LLQPTKPIILKV 492
            |:||||||||||..|...:.|..:|:||.|..|..|...::..:.. ||.|...|.|||
  Fly   433 GDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLKV 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a23-3a1	NP_037237.2	p450	39..492	CDD:278495	142/482 (29%)
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	141/478 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.970