DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a23-3a1 and Cyp6d2

DIOPT Version :9

Sequence 1:	NP_037237.2	Gene:	Cyp3a23-3a1 / 25642	RGDID:	628626	Length:	502	Species:	Rattus norvegicus
Sequence 2:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	149/533 - (27%)
Similarity:	258/533 - (48%)	Gaps:	72/533 - (13%)

- Green bases have known domain annotations that are detailed below.

  Rat    12 WVLLAVVLV--LLYGFGTRTHGLFKKQGI-PGPKPLPF--FGTVLNYYMGLWKFDVECHKKY-GK 70
            |.:|..:|:  |||.:..|.:..:::.|: ..|..:||  ..||:.....|.....:.:.:: ||
  Fly     2 WTILLTILIAGLLYRYVKRHYTHWQRLGVDEEPAKIPFGVMDTVMKQERSLGMALADIYARHEGK 66

  Rat    71 IWGLFDGQMPLFAITDTEMIKNVLVKECFSVFTNRRDFGPVGIMGKAISVSKD-----------E 124
            |.|::........|.|.::.:.::..: |:.|.:|         |..:...||           .
  Fly    67 IVGIYMLNKRSILIRDAQLARQIMTSD-FASFHDR---------GVYVDEDKDPLSANLFNLRGA 121

  Rat   125 EWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLR--QEKGKPVPVKEVFGAYSMDVITSTSF 187
            .|:..|..|:|:|:||::|.||..|:..||.||::|.  .::...|.:|:|...|::|:|.|..|
  Fly   122 SWRNLRQKLTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALDQSDEVEIKDVMTTYAVDIIGSVIF 186

  Rat   188 GVNVDSLNNPKDPFVEKAKK-------LLRIDFFDPLFLSVVLFPFLTPVYEMLNICMFPKDSIE 245
            |:.:||..|||:.|.|.:..       ||:|.     .:|:.:.|   |:.:::|...:....:.
  Fly   187 GLEIDSFRNPKNEFREISSSTSRDESLLLKIH-----NMSMFICP---PIAKLMNRLGYESRILT 243

  Rat   246 FFKKFVYRMKETRLDSVQKHRV---DFLQLMMNAHNDSKDKESHTALSDME-------------I 294
            ..:..:.|..|.|    ::|.|   |.|||::...|..|..|....:.|||             |
  Fly   244 SLRDMMKRTIEFR----EEHNVVRKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQLKSMSIEKI 304

  Rat   295 TAQSIIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRAL--PNKAPP---TYDTVMEMEY 354
            .||:.:|..||.|.|::..:|.|:.|:.:|:..|:.|||:|..|  .|..|.   ||:.|.::::
  Fly   305 AAQAFLFYVAGSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQDLKF 369

  Rat   355 LDMVLNETLRLYPIGNRLERVCKKDVEINGV--FMPKGSVVMIPSYALHRDPQHWPEPEEFRPER 417
            ||:.:.||:|.||....|.|.|.:|..:.|.  .:.||:.::|..:.:.|||.::|.|..:.|.|
  Fly   370 LDICIMETIRKYPGLPFLNRECTEDYPVPGTNHIIAKGTPILISLFGMQRDPVYFPNPNGYDPHR 434

  Rat   418 FSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQGLL 482
            |...|. :.|...|:|||.|||:||.:|...:|.|:|:.|:|.||........::..:.....:|
  Fly   435 FDSNNM-NYDQAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPRKEVEFRFDAAPVL 498

  Rat   483 QPTKPIILKVVPR 495
            ...:|:.|::..|
  Fly   499 VTKEPLKLRLTKR 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a23-3a1	NP_037237.2	p450	39..492	CDD:278495	140/498 (28%)
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	133/463 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920