DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a23-3a1 and Cyp6a8

DIOPT Version :9

Sequence 1:	NP_037237.2	Gene:	Cyp3a23-3a1 / 25642	RGDID:	628626	Length:	502	Species:	Rattus norvegicus
Sequence 2:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	159/523 - (30%)
Similarity:	257/523 - (49%)	Gaps:	57/523 - (10%)

- Green bases have known domain annotations that are detailed below.

  Rat     6 ALTLETWVLLAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTV--LNYYMGLWKFDVECHKKY 68
            |||...:.:...:|.:|..:..|....||::|||...|....|.:  |.....:.:...:.:.|:
  Fly     2 ALTYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKF 66

  Rat    69 ----GKIWGLFDGQMPLFAITDTEMIKNVLVKECFSVFTNRRDFGPVGIMGKAISVSKDE----- 124
                ....|.|..|.|...:.|.|:.|.:|:|: ||.|:|:      ||...    .||:
  Fly    67 RESKAPFVGFFFFQSPAAFVIDLELAKQILIKD-FSNFSNK------GIFYN----EKDDPISAH 120

  Rat   125 -------EWKRYRALLSPTFTSGRLKEMFPVIEQYGD--ILVKYLRQEKGKPVPVKEVFGAYSMD 180
                   :|:..|..||.|||||::|.|:|.:....:  :.|.:.:..|...:.::::...:::|
  Fly   121 LFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVD 185

  Rat   181 VITSTSFGVNVDSLNNPKDPFVEKAKKLLRIDFFDPLFLSVVL--FPFLTPVYEMLNICMFPKDS 243
            ||.:.:||:..:||.:.|..|:...|:.| :|......|:..:  :|.|.....|:......:
  Fly   186 VIGTCAFGIQCNSLRDEKAEFLYFGKRSL-VDKRHGTLLNGFMRSYPKLARKLGMVRTAPHIQ-- 247

  Rat   244 IEFFKKFVYRMKETRLDSVQKH--RVDFLQLMMNAHNDSKDKESHTALSDM-------EITAQSI 299
             ||:.:.|   .||.....::|  |.||:.:::...|   .||......|:       |:.||:.
  Fly   248 -EFYSRIV---TETVAVREKEHIKRNDFMDMLIELKN---QKEMTLENGDVVRGLTMEEVLAQAF 305

  Rat   300 IFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRALPNKAPP-TYDTVMEMEYLDMVLNETL 363
            :|..||:|.:|||:.|.|:.||.:||.|.|::.|::..:...... ||:...:::||:.||:|||
  Fly   306 VFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETL 370

  Rat   364 RLYPIGNRLERVCKKDVEING---VFMPKGSVVMIPSYALHRDPQHWPEPEEFRPERFSKENKGS 425
            |||.|...|:|:..|...:.|   ..:..|..|:|||.|:|.||..:|||.||||||||.|....
  Fly   371 RLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAG 435

  Rat   426 IDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQGLLQPTKP-II 489
            .....:||||:|||||||:||..|..::.|..:::||.|..|.:|..||....:..:...|. |.
  Fly   436 RPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGIY 500

  Rat   490 LKV 492
            |||
  Fly   501 LKV 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a23-3a1	NP_037237.2	p450	39..492	CDD:278495	147/488 (30%)
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	146/484 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870