Protein Alignment Cyp3a23-3a1 and Cyp6a23

DIOPT Version :10

• Sequence 1: NP_037237.2
• Gene: Cyp3a23-3a1 / 25642
• RGDID: 628626
• Length: 502
• Species: Rattus norvegicus
• Sequence 2: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Alignment Length: 507
• Identity: 167/507 - (32%)
• Similarity: 272/507 - (53%)
• Gaps: 44/507 - (8%)

  Rat    14 LLAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTVLNY----YMGLWKFDVECHKKYGKIWGL 74
            |:|:::.||.....|.||.::::|||...|.|.:|.:.::    ::.:...|.  :.||.:....
  Fly     7 LIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFRDY--YTKYKRSVYP 69

  Rat    75 FDGQMPLF----AITDTEMIKNVLVKECFSVFTNRRDF-----GPVGIMGKAISVSKDEEWKRYR 130
            |.|....|    .|||.|::|.||:|: |:.|.||..|     .|   :...:...:.::|:..|
  Fly    70 FAGFYFFFTRSAVITDLELVKRVLIKD-FNHFENRGIFYNEIDDP---LSATLFSIEGQKWRHLR 130

  Rat   131 ALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQE----KGKPVPVKEVFGAYSMDVITSTSFGVNV 191
            ..|:||||||::|.|||:|.:.|:.:.|....:    :|:.:.:.::...|:.|||.:.:||:|.
  Fly   131 HKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFGLNC 195

  Rat   192 DSLNNPKDPFVEKAKKLL-------RIDFFDPLFLSVVLFPFLTPVYEMLNICMFPKDSIEFFKK 249
            :||.||...||...|:.:       .:||.      :..||.|:   ..|.:.:..:|..:|:..
  Fly   196 NSLQNPNAEFVTIGKRAIIERRYGGLLDFL------IFGFPKLS---RRLRLKLNVQDVEDFYTS 251

  Rat   250 FVYRMKETRLDSVQKHRVDFLQLMMNAHNDSKDKESHTALSDMEITAQSIIFIFAGYEPTSSTLS 314
            .|....:.||.:.:| |.||:..::..:...:...:...||..||.||:.||..||:|.:|:|:.
  Fly   252 IVRNTIDYRLRTNEK-RHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFETSSTTMG 315

  Rat   315 FVLHSLATHPDTQKKLQEEIDRAL-PNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERVCKK 378
            |.|:.||...|.|.:|:.||:..| .:....||:.:.||:||:.|:.||||.||:...|.|:.:.
  Fly   316 FALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQT 380

  Rat   379 DV--EINGVFMPKGSVVMIPSYALHRDPQHWPEPEEFRPERFSKENKGSIDPYVYLPFGNGPRNC 441
            |.  |....|:.||:.|:||:..:|.||:.:||||:|:||||:.|...:.....:||||.|||||
  Fly   381 DFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNC 445

  Rat   442 IGMRFALMNMKLALTKVLQNFSFQPCKETQIPLK-LSRQGLLQPTKPIILKV 492
            ||:||.||...:.|..:::.:.|....|||||:| :.:..||.....|.|||
  Fly   446 IGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKV 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a23-3a1	NP_037237.2	CYP3A	67..491	CDD:410743	150/447 (34%)
Cyp6a23	NP_611000.2	CYP6-like	68..494	CDD:410679	147/439 (33%)