DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a23-3a1 and Cyp6a23

DIOPT Version :9

Sequence 1:	NP_037237.2	Gene:	Cyp3a23-3a1 / 25642	RGDID:	628626	Length:	502	Species:	Rattus norvegicus
Sequence 2:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	167/510 - (32%)
Similarity:	272/510 - (53%)	Gaps:	50/510 - (9%)

- Green bases have known domain annotations that are detailed below.

  Rat    14 LLAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTVLNY----YMGLWKFDVECHKKYGKIWGL 74
            |:|:::.||.....|.||.::::|||...|.|.:|.:.::    ::.:...|.  :.||.:....
  Fly     7 LIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFRDY--YTKYKRSVYP 69

  Rat    75 FDGQMPLF----AITDTEMIKNVLVKECFSVFTNRRDFGPVGI--------MGKAISVSKDEEWK 127
            |.|....|    .|||.|::|.||:|: |:.|.||      ||        :...:...:.::|:
  Fly    70 FAGFYFFFTRSAVITDLELVKRVLIKD-FNHFENR------GIFYNEIDDPLSATLFSIEGQKWR 127

  Rat   128 RYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQE----KGKPVPVKEVFGAYSMDVITSTSFG 188
            ..|..|:||||||::|.|||:|.:.|:.:.|....:    :|:.:.:.::...|:.|||.:.:||
  Fly   128 HLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFG 192

  Rat   189 VNVDSLNNPKDPFVEKAKKLL-------RIDFFDPLFLSVVLFPFLTPVYEMLNICMFPKDSIEF 246
            :|.:||.||...||...|:.:       .:||.      :..||.|:   ..|.:.:..:|..:|
  Fly   193 LNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFL------IFGFPKLS---RRLRLKLNVQDVEDF 248

  Rat   247 FKKFVYRMKETRLDSVQKHRVDFLQLMMNAHNDSKDKESHTALSDMEITAQSIIFIFAGYEPTSS 311
            :...|....:.||.:.:| |.||:..::..:...:...:...||..||.||:.||..||:|.:|:
  Fly   249 YTSIVRNTIDYRLRTNEK-RHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFETSST 312

  Rat   312 TLSFVLHSLATHPDTQKKLQEEIDRAL-PNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERV 375
            |:.|.|:.||...|.|.:|:.||:..| .:....||:.:.||:||:.|:.||||.||:...|.|:
  Fly   313 TMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRM 377

  Rat   376 CKKDV--EINGVFMPKGSVVMIPSYALHRDPQHWPEPEEFRPERFSKENKGSIDPYVYLPFGNGP 438
            .:.|.  |....|:.||:.|:||:..:|.||:.:||||:|:||||:.|...:.....:||||.||
  Fly   378 TQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGP 442

  Rat   439 RNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLK-LSRQGLLQPTKPIILKV 492
            |||||:||.||...:.|..:::.:.|....|||||:| :.:..||.....|.|||
  Fly   443 RNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKV 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a23-3a1	NP_037237.2	p450	39..492	CDD:278495	156/483 (32%)
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	154/477 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870