DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a23-3a1 and Cyp9h1

DIOPT Version :9

Sequence 1:	NP_037237.2	Gene:	Cyp3a23-3a1 / 25642	RGDID:	628626	Length:	502	Species:	Rattus norvegicus
Sequence 2:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	166/524 - (31%)
Similarity:	274/524 - (52%)	Gaps:	58/524 - (11%)

- Green bases have known domain annotations that are detailed below.

  Rat    14 LLAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTV-LNYYMG---LWKFDVECHKKY--GKIW 72
            |..::|||||.:....:.:|.::|:...||.|..|.: |...:|   :.|..:|.|.|:  ..::
  Fly    10 LFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKMIELHTKHTGSPVY 74

  Rat    73 GLFDGQMPLFAITDTEMIKNVLVKECFSVFTNRRDFG---PVGIMGKAISVSKDEEWKRYRALLS 134
            |::..:..:|.:.|.|:||.:.:|| |..|.|.....   ...|:.|::...:|..||..|.:|:
  Fly    75 GIYALRDAVFFVRDPELIKLIGIKE-FDHFVNHNSMHNNIQESILSKSLISLRDGRWKEMRNILT 138

  Rat   135 PTFTSGRLKEMFPVIE---QYGDILVK---YLRQEKGKPVPVKEVFGAYSMDVITSTSFGVNVDS 193
            |.||..:::.|:.:|:   :.|.|.::   .|.|:....:.:|:.|..::.|||.:.:||::::|
  Fly   139 PAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDVIATVAFGISINS 203

  Rat   194 LNNPKDPFVEKAKKLLRIDFFDPLFLSVV------LFPFLTPVYEMLNICMFPKDSIEFFKKFVY 252
            .....:.|....:.:.||..:     |||      |||.|..|   |.|.:....:|::|...|.
  Fly   204 FRRKDNEFFRIGQAMSRISAW-----SVVKAMLYALFPRLMKV---LRIQVLDTKNIDYFSSLVT 260

  Rat   253 RMKETRLDSVQKHRV---DFLQLMMNA--------HNDSKDKESHTALSDMEITAQSIIFIFAGY 306
            .....|    |:|:|   |.:.|:|.|        .:.|||:..::..:..::.||.::|.|||:
  Fly   261 AAMRYR----QEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFFFAGF 321

  Rat   307 EPTSSTLSFVLHSLATHPDTQKKLQEEI---DRALPNKAPPTYDTVMEMEYLDMVLNETLRLYPI 368
            |..||:|.|:.|.|..:|..|.:|.|||   ...|..: |.|||.:.:|:|||||:.|.||.:|.
  Fly   322 EIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQ-PLTYDKLTKMKYLDMVVLEALRKWPP 385

  Rat   369 GNRLERVCKKDVEI---NG--VFMP-KGSVVMIPSYALHRDPQHWPEPEEFRPERFSKENKGSID 427
            ....:|.|::|:::   ||  :|.. ||.|:.||.::||.||:::.:||.|.||||:..:  :::
  Fly   386 SISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERFADGH--ALE 448

  Rat   428 PYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQGL-LQPTKPIILK 491
            ..||:|||.|||||||.|.|||.:|..:.::|.||...|.|.|...|....:|. |:|.....||
  Fly   449 SRVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLNDIRGHGLKPKNGFWLK 513

  Rat   492 VVPR 495
            ...|
  Fly   514 FEAR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a23-3a1	NP_037237.2	p450	39..492	CDD:278495	156/494 (32%)
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	155/489 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133568
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm9060
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.870