DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp3a23-3a1 and Cyp6t3

DIOPT Version :9

Sequence 1:	NP_037237.2	Gene:	Cyp3a23-3a1 / 25642	RGDID:	628626	Length:	502	Species:	Rattus norvegicus
Sequence 2:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	143/511 - (27%)
Similarity:	240/511 - (46%)	Gaps:	51/511 - (9%)

- Green bases have known domain annotations that are detailed below.

  Rat    12 WVLLAVVLVLLYGFGTR-THGLFKKQGIP-----GPKPLPFFGTVL-------NYYMGLWKFDVE 63
            |:||..::.|  .|..| .:..|:.:|||     ...|:...|.:|       :.:..|:   .:
  Fly     5 WLLLLTIVTL--NFWLRHKYDYFRSRGIPHLPPSSWSPMGNLGQLLFLRISFGDLFRQLY---AD 64

  Rat    64 CHKKYGKIWGLFDGQMPLFAITDTEMIKNVLVKECFSVFTNR---RDFG-PVGIMGKAISVSKDE 124
            ......||.|.|..|.|...:.|.|:|:.||:|. |:.|.||   .|.| |:|.:  .:.::|..
  Fly    65 PRNGQAKIVGFFIFQTPALMVRDPELIRQVLIKN-FNNFLNRFESADAGDPMGAL--TLPLAKYH 126

  Rat   125 EWKRYRALLSPTFTSGRLKE-MFPVIEQYGDILVKYLRQEKG----KPVPVKEVFGAYSMDVITS 184
            .||..|..:|..|||||::: |:..:......|.:||.::.|    :.:|:..:...|:.||..:
  Fly   127 HWKESRQCMSQLFTSGRMRDVMYSQMLDVASDLEQYLNRKLGDRLERVLPLGRMCQLYTTDVTGN 191

  Rat   185 TSFGVNVDSLNNPKDPFVEKAKKLLRIDFFDPL-FLSVVLFPFLTPVYEMLNICMFPKDSIEFFK 248
            ..:.:||..|...:...:.|.|:|...:....| |:||...|..|.|.:       ||...|.:.
  Fly   192 LFYSLNVGGLRRGRSELITKTKELFNTNPRKVLDFMSVFFLPKWTGVLK-------PKVFTEDYA 249

  Rat   249 KFVYRMKETRLDSVQKHRVDFLQLMMNAHNDSKDKESHTALSDMEITAQSIIFIFAGYEPTSSTL 313
            :::..:.:...:..:...::.||     |.......:|.:.....:.:|:.|.:.||:|.:|:.:
  Fly   250 RYMRHLVDDHHEPTKGDLINQLQ-----HFQLSRSSNHYSQHPDFVASQAGIILLAGFETSSALM 309

  Rat   314 SFVLHSLATHPDTQKKLQEEIDRALPNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERVCKK 378
            .|.|:.||..||.|::|:.|:..|..:.|..:|||:|.:.||.||..|.|||||....:.|.|..
  Fly   310 GFTLYELAKAPDIQERLRSELREAFISTATLSYDTLMTLPYLKMVCLEALRLYPAAAFVNRECTS 374

  Rat   379 DVEINGVFMPKGSVVM---IPSY----ALHRDPQHWPEPEEFRPERFSKENKGSIDPYVYLPFGN 436
            .........|....::   :|:|    .||||.:.||||..|.||||..|....|.|..|:|||.
  Fly   375 SASEGFSLQPHVDFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPERSRHIHPMTYIPFGA 439

  Rat   437 GPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLS-RQGLLQPTKPIILK 491
            ||..|||.|..::.:||.:..:|:.:..:.|:.|...::.: :..:|:....|.|:
  Fly   440 GPHGCIGSRLGVLQLKLGIVHILKQYWVETCERTVSEIRFNPKSFMLESENEIYLR 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a23-3a1	NP_037237.2	p450	39..492	CDD:278495	134/483 (28%)
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	130/469 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920