DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a23-3a1 and Cyp28a5

DIOPT Version :9

Sequence 1:	NP_037237.2	Gene:	Cyp3a23-3a1 / 25642	RGDID:	628626	Length:	502	Species:	Rattus norvegicus
Sequence 2:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	137/535 - (25%)
Similarity:	247/535 - (46%)	Gaps:	82/535 - (15%)

- Green bases have known domain annotations that are detailed below.

  Rat     7 LTLETWVLLAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTVLNYYM----GLWKFDVECHKK 67
            :.|.|..|:::|:.|||......:..::|:|:|||||....|...|.:.    .::..| :.:::
  Fly     1 MVLITLTLVSLVVGLLYAVLVWNYDYWRKRGVPGPKPKLLCGNYPNMFTMKRHAIYDLD-DIYRQ 64

  Rat    68 YGKIW---GLFDGQMPLFAIT-----------------DTEMIKNVLVKECFSVFTNRRDFGPVG 112
            |...:   |:|..:.|...:.                 |.|:.||:..|..| :|.|    .|..
  Fly    65 YKNKYDAVGIFGSRSPQLLVINPALARRVFVSNFKNFHDNEIAKNIDEKTDF-IFAN----NPFS 124

  Rat   113 IMGKAISVSKDEEWKRYRALLSPTFTSGRLKEMFP----VIEQYGDILVKYLRQEKGKPVPVKEV 173
            :.|        |:||..||.::|..|.||:|.::|    |.::..:.:.|.||......:..|.:
  Fly   125 LTG--------EKWKTRRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLGSKDGIDAKHM 181

  Rat   174 FGAYSMDVITSTSFGVNVDSLNNPKDPFVEKAKKLLRIDF-FDPLFLSVVLFPFLTPVYEMLNIC 237
            ...::.:::|....|:..:|.::...|.:.|...|....: |...|:....||.|:   .::.:.
  Fly   182 SLCFTTEMVTDCVLGLGAESFSDKPTPIMSKINDLFNQPWTFVLFFILTSSFPSLS---HLIKLR 243

  Rat   238 MFPKDSIEFFKKFVYRMKETRLDSV----QKHRVDFLQLMMNAHNDSKDKESHTALSDMEITAQS 298
            ..|.|...||...:....|||...:    |..|.|||..::..    .:|.:   |.:.::.|.|
  Fly   244 FVPVDVERFFVDLMGSAVETRRAQLAAGKQFERSDFLDYILQL----GEKRN---LDNRQLLAYS 301

  Rat   299 IIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRALPNKAPPTYDTVMEMEYLDMVLNETL 363
            :.|:..|:|.|::.|:.:|.:|..:.:.|..|:||| |:........::.:.::.|||..:.||:
  Fly   302 MTFLLDGFETTATVLAHILLNLGRNKEAQNLLREEI-RSHLQDGTIAFEKLSDLPYLDACVQETI 365

  Rat   364 RLYPIGNRLERVCKKDVEINGVFMP-----KGSVVMIPSYALHRDPQHWPEPEEFRPERFSKEN- 422
            ||:|.|....::|.:.:||.....|     ||:.|::|.|....|.:.:|.|:.|:||||.:.:
  Fly   366 RLFPPGFMSNKLCTESIEIPNKEGPNFVVEKGTTVVVPHYCFMLDEEFFPNPQSFQPERFLEPDA 430

  Rat   423 -KGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQGLLQPTK 486
             |...:..|::.||:|||.|||||||.:.:|.|:.:::..|:      .:|..|..:....:|
  Fly   431 AKTFRERGVFMGFGDGPRVCIGMRFATVQIKAAIVELISKFN------VKINDKTRKDNDYEP-- 487

  Rat   487 PIILKVVPRDEIITG 501
                     .:||||
  Fly   488 ---------GQIITG 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a23-3a1	NP_037237.2	p450	39..492	CDD:278495	124/492 (25%)
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	128/503 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920