DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a23-3a1 and Cyp28d1

DIOPT Version :9

Sequence 1:	NP_037237.2	Gene:	Cyp3a23-3a1 / 25642	RGDID:	628626	Length:	502	Species:	Rattus norvegicus
Sequence 2:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	483	Identity:	139/483 - (28%)
Similarity:	239/483 - (49%)	Gaps:	41/483 - (8%)

- Green bases have known domain annotations that are detailed below.

  Rat    14 LLAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTVLNYYMG----LWKFD--VECHKKYGKIW 72
            ::|.:|.|:|.|.|.....:||:|||..|..||.|:..:.:..    ::..|  .|.:|....|.
  Fly    10 VIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQYKNTDSIV 74

  Rat    73 GLFDGQMPLFAITDTEMIKNVLVKECFSVFTNR----RDFGPVGIMGKAISVSKDEEWKRYRALL 133
            |:|..::|...:|..|....:.|.:..|...|.    .|.....|:.....|...|.||..||.:
  Fly    75 GVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPFVLTGEAWKERRAEV 139

  Rat   134 SPTFTSGRLKEMFPVIEQYGDILVKYLRQEK----GKPVPVKEVFGAYSMDVITSTSFGVNVDSL 194
            :|..::.|:|..:||..:.....|:|:|::.    .:.:..|::...|:.:||:....|::..|.
  Fly   140 TPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVISDCVLGISAQSF 204

  Rat   195 NNPKDPFVEKAKKLLRIDFFDPLFLSVV--LFPFLTPVYEMLNICMFPKDSIEFFKKFVYRMKET 257
            .:...|.|...|::.. ..|..:|.:||  |:|   |:.:..::.:|.||...||...:.:..:.
  Fly   205 TDNPTPMVGMTKRVFE-QSFGFIFYTVVANLWP---PITKFYSVSLFAKDVAAFFYDLMQKCIQV 265

  Rat   258 RLDS-VQKHRVDFLQLMMNAHNDSKDKESHTALSDMEITAQSIIFIFAGYEPTSSTLSFVLHSLA 321
            |.:| ..:.|.|||..|:..       :....|:..|:|:.::.|:..|:|.|:..|:..|..||
  Fly   266 RRESPAAQQRDDFLNYMLQL-------QEKKGLNAAELTSHTMTFLTDGFETTAQVLTHTLLFLA 323

  Rat   322 THPDTQKKLQEEIDRALPNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERVCKKDVEI---N 383
            .:|..|.||:|||     ..|..|::.:.|:.:.:..::||||::.......:|..:..|:   |
  Fly   324 RNPKEQMKLREEI-----GTAELTFEQISELPFTEACIHETLRIFSPVLAARKVVTEPCELTNKN 383

  Rat   384 GVF--MPKGSVVMIPSYALHRDPQHWPEPEEFRPERFSKENKGS---IDPYVYLPFGNGPRNCIG 443
            ||.  :..|.||:||..|||.|||::.||:.|:||||...|.|:   .|..::..||:|||.|.|
  Fly   384 GVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQGLFFGFGDGPRICPG 448

  Rat   444 MRFALMNMKLALTKVLQNFSFQPCKETQ 471
            |||:|..:|.||.::::||..:...:|:
  Fly   449 MRFSLTQIKAALVEIVRNFDIKVNPKTR 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a23-3a1	NP_037237.2	p450	39..492	CDD:278495	129/458 (28%)
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	129/458 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920