DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a23-3a1 and Cyp28c1

DIOPT Version :9

Sequence 1:	NP_037237.2	Gene:	Cyp3a23-3a1 / 25642	RGDID:	628626	Length:	502	Species:	Rattus norvegicus
Sequence 2:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	132/528 - (25%)
Similarity:	232/528 - (43%)	Gaps:	74/528 - (14%)

- Green bases have known domain annotations that are detailed below.

  Rat    15 LAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTVLNYYMGLWKF-----DVECHKKYGKIW-G 73
            :|.:|..:|.|.....|.::::|:..|:.||.||:..|.......|     |:..|.:....: |
  Fly     9 IATLLGAIYAFLVSNFGHWRRRGVTEPRALPLFGSFPNMIWPRQHFTMDMRDIYMHYRNTHSYVG 73

  Rat    74 LFDGQMPLFAITDTEMIKNVLVKECFSVFTNRRDFGPVGIMGKAISVSKD------------EEW 126
            .:..:.|...:.:..::..:.| ..||.|.|..       ..|.:.::||            |||
  Fly    74 CYLLRAPKLLVLEPRLVYEIYV-SAFSHFENND-------ASKMVDIAKDRLVALNPFVLEGEEW 130

  Rat   127 KRYRALLSPTFTSGRLKEMFPVIEQYGDILVKY--LRQEKGKPVPVKEVFGAYSMDVITSTSFGV 189
            :..||:.|...|:||::....::::....|.::  ::...||.:...::...::.:.:.....|:
  Fly   131 RHQRAVFSTLLTNGRIRTTHAIMQRVCLDLCQFIAIKSAGGKDLDCIDLGLRFTGESLFDCVLGI 195

  Rat   190 NVDSLNNPKDPFVEKAKKLLRIDFFDPLFLSVV-----LFPFLTPVYEMLNICMFPKDSIEFFKK 249
            ...:..:...|.|.:..::..    :...|::.     |||.|.   ..|...:||:....|:.:
  Fly   196 QARTFTDNPLPVVRQNHEMSA----ENRGLAIAGAVHGLFPNLP---RWLRPKVFPRSHDRFYGQ 253

  Rat   250 FVYRMKETRLDSVQKHRVDFLQLMMNAHNDSKDKESHTALSDMEITAQSIIFIFAGYEPTSSTLS 314
            .:......| .|..:.|.||:       |...:.:....||:.::.:.::.|:|.|.:.||::::
  Fly   254 MISEALRLR-RSKHQERNDFI-------NHLLEMQRELDLSEEDMASHAMTFMFDGLDTTSNSIA 310

  Rat   315 FVLHSLATHPDTQKKLQEEIDRALPNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERVCKKD 379
            ..|..|..:||.|::|.||:....|....|..|.::::.||....||:||:||.|....:.|.|:
  Fly   311 HCLLLLGRNPDCQRRLYEELQLVNPGGYLPDLDALIDLPYLSACFNESLRIYPAGGWASKTCTKE 375

  Rat   380 VEING------VFMPKGSVVMIPSYALHRDPQHWPEPEEFRPERFSKEN-KGSIDPYVYLPFGNG 437
            .|:.|      :.:..|..||:|.||||.||..:|||:.||||||.... |......::|.||||
  Fly   376 YELRGSHHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNCKQQGIFLGFGNG 440

  Rat   438 PRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQGLLQPTKPII----------LKV 492
            ||.|:|||..|...|.||..::|.|.......|....:|.         |:|          |:.
  Fly   441 PRQCVGMRLGLAMAKAALAAIVQRFEVVVSPRTLNGTELD---------PLIFVGVHKGGIWLQF 496

  Rat   493 VPRDEIIT 500
            |||..:.|
  Fly   497 VPRKNVTT 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a23-3a1	NP_037237.2	p450	39..492	CDD:278495	122/494 (25%)
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	121/483 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920