Protein Alignment Cyp3a23-3a1 and Cyp6a16

DIOPT Version :10

• Sequence 1: NP_037237.2
• Gene: Cyp3a23-3a1 / 25642
• RGDID: 628626
• Length: 502
• Species: Rattus norvegicus
• Sequence 2: NP_001285631.1
• Gene: Cyp6a16 / 19836250
• FlyBaseID: FBgn0031726
• Length: 498
• Species: Drosophila melanogaster
• Alignment Length: 520
• Identity: 165/520 - (31%)
• Similarity: 264/520 - (50%)
• Gaps: 65/520 - (12%)

  Rat    11 TWVLLAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTVLN----YYMGLWKFDVECHKKYGKI 71
            |.:||..:|..|.|:.......::.:|||..:|...||....    :|..|.:...:..:...|:
  Fly     4 TLLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGHFFRLQSVHYSELLQETYDAFRGSAKV 68

  Rat    72 WGLFDGQMPLFAITDTEMIKNVLVKECFSVFTNRRDFGPVGIMGKAISVSKDEEWKRYRALLSPT 136
            .|.:....|:..:.|.:::|.||::: |:.|.:||.|....:.....:: :.|||:..|..||||
  Fly    69 AGTYVFLRPMAVVLDLDLVKAVLIRD-FNNFVDRRSFHGDPLTANLFNL-QGEEWRNLRTKLSPT 131

  Rat   137 FTSGRLKEMF----PVIEQYG---DILVKYLRQEKGKPVPVKEVFGAYSMDVITSTSFGVNVDSL 194
            ||||::|.||    .|.:|.|   |.||    ..:|..:.:.::...|:.|||.|.:||....||
  Fly   132 FTSGKMKYMFGTVSTVAQQLGGTFDELV----GSQGAVLELHDLMARYTTDVIGSCAFGTECSSL 192

  Rat   195 NNPKDPFVEKAKKL-------LRIDFFDPLFLSV---------VLFPFLTPVYEMLNICMFPKDS 243
            ..|:..|.:..:::       :|...|...:||.         :|.|.:|
  Fly   193 REPQAEFRQVGRRIFRNSNRSIRWRIFKMTYLSSLAKLGLPVRILHPDIT--------------- 242

  Rat   244 IEFFKKFVYRMKETRLDSVQKHRVDFLQLMMNAHNDSKDKESHTALSDMEITAQSIIFIFAGYEP 308
             :||.:.|....|.| :.....|.||:.|::    |.:.:|:...|:..::.||:.:|..||:|.
  Fly   243 -KFFNRIVRETVELR-ERENIRRNDFMDLLL----DLRRQENGKGLTMEQMAAQAFVFFVAGFET 301

  Rat   309 TSSTLSFVLHSLATHPDTQKKLQEEIDRALPNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLE 373
            :||.:|:.|..||.:.|.|:||:.||:.::......||:.:|||.|||..:.||||.||..:.|.
  Fly   302 SSSNMSYALFELAKNQDVQQKLRMEINDSIGKHGKLTYEAMMEMPYLDQTITETLRKYPALSSLT 366

  Rat   374 RVCKKDVEI------NGVFMPKGSVVMIPSYALHRDPQHWPEPEEFRPERFSKENKGSIDPYVYL 432
            |:..:|.||      :.|.:.||:.|.||..|:|.||:.:|||.|||||||:.:......|..:|
  Fly   367 RLASEDYEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHPTAFL 431

  Rat   433 PFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQ--PCKETQIPLKLSRQGL-LQPTKPIILKVVP 494
            .||:|||||||:||..|.:|:.|..:|:.|.|.  |...||  ||::::.| |.|:..:.|:|.|
  Fly   432 GFGDGPRNCIGLRFGRMQVKVGLITLLRRFRFSLPPGSPTQ--LKVTKRNLILLPSDGVRLQVDP 494

  Rat   495  494
              Fly   495  494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a23-3a1	NP_037237.2	CYP3A	67..491	CDD:410743	148/455 (33%)
Cyp6a16	NP_001285631.1	CYP6-like	64..489	CDD:410679	148/453 (33%)