DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCML4 and scml4

DIOPT Version :9

Sequence 1:	XP_016866166.1	Gene:	SCML4 / 256380	HGNCID:	21397	Length:	442	Species:	Homo sapiens
Sequence 2:	XP_001332433.4	Gene:	scml4 / 794170	ZFINID:	ZDB-GENE-041210-338	Length:	475	Species:	Danio rerio

Alignment Length:	453	Identity:	249/453 - (54%)
Similarity:	299/453 - (66%)	Gaps:	63/453 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    13 PVSDLSPHSVRLAPA------EMQSQ-------------RIPGRKRGRPSLHSTPMKMAVHNLYS 58
            |....|..|:..||:      ||||.             ::||||||||.|...|      ...|
Zfish    63 PTCSQSLMSIPAAPSVQSGGGEMQSPGVISPSFLPPASGKVPGRKRGRPPLKRHP------EYQS 121

Human    59 ASAGSLPAVKIPKKRGRKPGYKIKSRVLMTPLALSPPRSTPEPDLSSIPQDAATVPSLAAPQALT 123
            ....|||.:|:|||||||||:|:||| ||||||:|||.||||||:|||||||||:|..|.||.||
Zfish   122 RYPESLPPIKVPKKRGRKPGFKLKSR-LMTPLAISPPSSTPEPDMSSIPQDAATIPHSATPQVLT 185

Human   124 VCLYINKQANAGPYLERKKVQQLPEHFGPERPSAVLQQAVQACIDCAHQQKLVFSLVKQGYGGEM 188
            ||:|:|||.|.||.|:|:||.|||:|.||.|||.|||||||.|||.|.|||.||:|:.:|||||
Zfish   186 VCIYVNKQVNTGPNLDRQKVLQLPDHLGPARPSVVLQQAVQGCIDSAFQQKAVFTLLTEGYGGE- 249

Human   189 VSVSASFDGKQHLRSLPVVNSIGYVLRFLAKLCRSLLCDDLFSHQPFPRGCSASEK----VQEKE 249
             .:||:|||||||.|||||||:|||||||.||||||||::|||.||.....|.|..    :::..
Zfish   250 -KISATFDGKQHLLSLPVVNSVGYVLRFLKKLCRSLLCENLFSDQPIAPSSSPSSSSSFHMEKHS 313

Human   250 EGRMESVKTVTTEEYLVNPVGMNRYSVDTSASTFNHRGSLHPSSSLYCKRQNSGDSHLGGGPAAT 314
            :|:.:|...|  ::|..:.|...|||||  .|.|....|.:.:|.                   .
Zfish   314 DGQSKSNSMV--DDYHGDSVEPKRYSVD--PSDFGAMSSPYAASK-------------------P 355

Human   315 AGGPRTSPMSSGGPSAPGLRPPASSPKRNTTSLEGNRCASSPSQDAQDARRPRSRNPSAWTVEDV 379
            |.|.|::...||     |:...|:||   :|..||||.|.|||.||.:.:.|.|::||.|:|::|
Zfish   356 AYGFRSASAYSG-----GICRQAASP---STFPEGNRSAYSPSPDAGEVKPPPSKDPSRWSVDEV 412

Human   380 VWFVKDADPQALGPHVELFRKHEIDGNALLLLKSDMVMKYLGLKLGPALKLCYHIDKLKQAKF 442
            |||:||||||||||||||||||||||:|||||||||:|||||||||||||||||||||||.||
Zfish   413 VWFIKDADPQALGPHVELFRKHEIDGDALLLLKSDMIMKYLGLKLGPALKLCYHIDKLKQNKF 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCML4	XP_016866166.1	None
scml4	XP_001332433.4	DUF3588	185..293	CDD:288954	79/109 (72%)
		SAM_Scm	401..472	CDD:188977	61/70 (87%)
		SAM	404..472	CDD:197735	60/67 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194335545
Domainoid	1	1.000	167	1.000	Domainoid score	I15843
eggNOG	1	0.900	-	-		E1_KOG3766
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H18262
Inparanoid	1	1.050	368	1.000	Inparanoid score	I8422
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG41951
OrthoDB	1	1.010	-	-		D123551at33208
OrthoFinder	1	1.000	-	-		FOG0012303
OrthoInspector	1	1.000	-	-		oto47513
orthoMCL	1	0.900	-	-		OOG6_120609
Panther	1	1.100	-	-	LDO	PTHR12247
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7167
SonicParanoid	1	1.000	-	-		X10243
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300