Protein Alignment SCML4 and l(3)mbt

DIOPT Version :10

• Sequence 1: XP_047274551.1
• Gene: SCML4 / 256380
• HGNCID: 21397
• Length: 467
• Species: Homo sapiens
• Sequence 2: NP_733209.1
• Gene: l(3)mbt / 43288
• FlyBaseID: FBgn0002441
• Length: 1477
• Species: Drosophila melanogaster
• Alignment Length: 693
• Identity: 134/693 - (19%)
• Similarity: 200/693 - (28%)
• Gaps: 295/693 - (42%)

Human     7 PGRKRGRPSLHSTPMKMAVH--NLYSASAG-------SLPAVKIPKKRGRKPGYKKPKATTKTNA 62
            |||   |||....|:.....  |.:..:|.       |:..|:..:||      :.|::|.|.:.
  Fly   715 PGR---RPSACVHPLLYLCQRCNFHGPAADFLAPHFCSVGCVRRSQKR------RLPQSTQKESK 770

Human    63 LPENSLDRLRQAENPPIPLERDQVSGSHDSLSPL------TSAEYPRARPQLHPSGRSHGPQLGG 121
            :....|:: .....|.:|.:|......|.|||.:      ...:.||...:.....:|.|..:..
  Fly   771 ISRTQLEQ-TAGTAPDLPQKRQTNYKPHKSLSAIQEQLQQRQKDKPRKPFRWSEYLKSKGKDVAA 834

Human   122 PTGSHRFPKD-PIRPQSDPL--------PSNPVRVAVC----------------------LYINK 155
            |.  |.|... ||.|....:        |.|.....||                      .::|.
  Fly   835 PI--HLFLNPFPISPNCFEIGMKLEAIDPENCSLFCVCSIVEVRGYRLKLSFDGYSSMYDFWVNA 897

Human   156 QAN----AGPYLERKKVQQLPEHFGPERPSAVLQQAVQACIDCAHQQKLVFS----LVKQG---- 208
            .:.    .|...|..:|.|.|:.:..||                      ||    |||.|
  Fly   898 DSQDIFPPGWCDETARVLQAPKDYNSER----------------------FSWSRYLVKTGGKAA 940

Human   209 ----YG----GEMVSVSASFDGKQHLRSLPVVNSIGYVLRFLAKLCRSLL--------------- 250
                :|    .:.:.|...|....||.: ..:|..|       |:|.:.:
  Fly   941 PRALFGHLNMQQQMDVRNGFAVGMHLEA-EDLNDTG-------KICVATVTDILDERIRVHFDGW 997

Human   251 --CDDLFSH--QPFPRGCSASEKVQE------------------KEEGRMESVKTVTTE----EY 289
              |.||:.|  .|:...|...|..|:                  .|.|.|.:.|.:.|.    ||
  Fly   998 DDCYDLWVHITSPYIHPCGWHEGRQQLIVPPDYQKSAFIWDDYISEVGGMAASKELFTPRQPMEY 1062

Human   290 ---------------LVNPVGMNRYSVDTSASTFNHRGSLH----PSSSLYCKRQNSGDSHLGGG 335
                           |:.|.        |..:...:|..||    |:...:....:|.|.|..|.
  Fly  1063 QERMKLEVVDQRNPCLIRPA--------TVVTRKGYRVQLHLDCWPTEYYFWLEDDSPDLHPIGW 1119

Human   336 PAATAGGPRTSP-------------------------------MSSGGPSAP---------GLRP 360
            ..||:....|.|                               :....|.||         .::|
  Fly  1120 CEATSHELETPPGYLQPKSVMPCDVEGCRGFGNAKRFNLNVHALRECCPYAPENWRQWRSKTVKP 1184

Human   361 PASSPK--RNTTSLEGNRCASSPSQ----DAQ------------DARRPRS-------------- 393
            |..:|:  |...:.:..|..|...|    |:|            .|:|..|
  Fly  1185 PRVAPENIRRGWAKKTKRACSEAKQAIKEDSQQEIVYPKVAEVVQAKRKTSPCEEKVVKKQKQMQ 1249

Human   394 RNPSAWTVED------VVWFVKDADPQALGPHVELFR---------------------------- 424
            :...|..|.|      ...||||..||.| |:..|::
  Fly  1250 KEEDAEQVPDERSLAIARSFVKDYGPQFL-PNYRLWQLNSAFKLDDVRTNPLHWTSWDVCEYIER 1313

Human   425 ------------KHEIDGNALLLLKSDMVMKYLGLKLGPALKL 455
                        :.:|||.|||:|....:..||.||:|||:||
  Fly  1314 ALDSTDIAKVIFEQDIDGRALLMLGRKELDTYLKLKVGPAVKL 1356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCML4	XP_047274551.1	RBR	1..53	CDD:465382	13/54 (24%)
		SLED	149..258	CDD:463469	29/169 (17%)
		SAM_Scm	393..464	CDD:188977	29/123 (24%)
l(3)mbt	NP_733209.1	PRK10819	<332..>427	CDD:236768
		MBT_L3MBTL1-like_rpt1	846..945	CDD:439091	19/120 (16%)
		MBT_L3MBTL1-like_rpt2	957..1045	CDD:439092	16/95 (17%)
		MBT_L3MBTL1-like_rpt3	1058..1130	CDD:439093	15/79 (19%)
		SAM_PNT	1278..1367	CDD:460486	19/80 (24%)