DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde4a and Pde11

DIOPT Version :9

Sequence 1:	NP_037233.4	Gene:	Pde4a / 25638	RGDID:	3279	Length:	844	Species:	Rattus norvegicus
Sequence 2:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster

Alignment Length:	480	Identity:	120/480 - (25%)
Similarity:	212/480 - (44%)	Gaps:	88/480 - (18%)

- Green bases have known domain annotations that are detailed below.

  Rat   378 SCIMYTIFQERDLLKKFHIPVDTMMMYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDA 442
            :|:  .:|.:.|.:::|||..:.:..::|:::.:|. :|.|||..||.:|.|....:|.|.....
  Fly   822 ACL--RMFLDLDFVERFHIDYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILTTTQWWK 883

  Rat   443 VFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEENCDI 507
            :|.::|.||.:.....||:||.|.:|.|.|..:|.||.:|: .|.:|:||......:|......|
  Fly   884 IFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNSPGNQI 947

  Rat   508 FQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLR-- 570
            ..|||......:.:::.|.:|:||::.:.......  :....:.||..|.     .:...:||
  Fly   948 LANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPF--LESVSQPTSYWVA-----EEPRALLRAM 1005

  Rat   571 NMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISP---MCDKHTASVEKSQVGFI 632
            :|..| |||..|||.|:.::..|.:.:|||:|||.|::. :.|:|   |..:....:...||.||
  Fly  1006 SMTVC-DLSAITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPIDIMNREKEDELPMMQVNFI 1068

  Rat   633 DYIVHPLWETWADLVHPDAQDILDTLEDNRDWYHSAIRQSPSPPLEEEPGGLGH-PSLPDKFQFE 696
            |.|..|::|.:|.| ....:.:::.:.|||                      || ..|.|..:.:
  Fly  1069 DSICLPIYEAFATL-SDKLEPLVEGVRDNR----------------------GHWIDLADVVKTK 1110

  Rat   697 LTLEEEEEEDSLEVPGLPTTEETFLAAEDARAQAVDWSKVKGPSTTVVEVAERLKQETASAYGA- 760
            .:.::|.||:.        .::..::..|.:|.:.|     ..:.:..|||.....|.||..|:
  Fly  1111 TSQDQEPEEEQ--------QQQNVISNGDCKAMSDD-----DVAASEAEVAVDSPSEKASVNGSN 1162

  Rat   761 ----PQESMEAVGCSFSPGTPILP------------DVRTLSSSEEAPGLLGLPSTAAEVEAPRD 809
                ...:.:.:..:..| |...|            ||...::.|....        |||:.
  Fly  1163 VANNSSNTNKKIAVASHP-TSTQPSDDDNDVDADADDVDEQAAEENGHD--------AEVDE--- 1215

  Rat   810 HLAATRACSACSGTSGDNSAIISTP 834
              |:.|:.|.||.::.  |:.:|||
  Fly  1216 --ASCRSNSTCSSSTA--SSCLSTP 1236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde4a	NP_037233.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..124
		PDE4_UCR	173..288	CDD:407935
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..317
		PDEase_I	418..659	CDD:395177	73/245 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..690		2/22 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..844		7/17 (41%)
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500
		PDEase_I	859..1094	CDD:278654	73/245 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347771
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750