Protein Alignment GK5 and Gk2

DIOPT Version :10

• Sequence 1: NP_001034636.1
• Gene: GK5 / 256356
• HGNCID: 28635
• Length: 529
• Species: Homo sapiens
• Sequence 2: NP_647655.1
• Gene: Gk2 / 38221
• FlyBaseID: FBgn0035266
• Length: 576
• Species: Drosophila melanogaster
• Alignment Length: 555
• Identity: 160/555 - (28%)
• Similarity: 263/555 - (47%)
• Gaps: 72/555 - (12%)

Human    11 RAQEPR------YPGFVLGLDVGSSVIRCHVYD-------RAARVCGSSVQKVENLYPQIGWVEI 62
            |::|.|      :.|.|..:|.|:..|...:|.       .|.||      ::..:.||.||.|.
  Fly    17 RSKELRKQSLIQHTGLVGVIDEGTKTIGFSIYTTPDFKEIAAHRV------ELSVITPQDGWYEQ 75

Human    63 DPDVLWIQFVAVIKEAVK---AAGIQMNQIVGLGISTQRATFITWNKKTGNHFHNFISWQDLRAV 124
            ||..:........:||:|   ..|...:.||.:||:.||.|.|.|:..||...:|.:.|:|:|..
  Fly    76 DPLEMMASINKCAEEAIKQLPEQGFSASDIVTVGITNQRETTIVWDAVTGKPLYNALLWKDIRTS 140

Human   125 ELVKSWNNSLLMKIFHSSCRVLHFFTRSKRLFTASLFTFTTQQTSLRLVWILQNLTEVQKAVEEE 189
            ..|:    .::.|:...:    ||  ||     ::....:|..::|::.|:..|:.||::|:.|.
  Fly   141 TTVE----QIVAKVQDPN----HF--RS-----STGLPISTYFSALKIRWLRDNVPEVRQAIRER 190

Human   190 NCCFGTIDTWLLYKLTKGSVYATDFSNASTTGLFDPYKMCWSGMITSLISIPLSLLPPVRDTSHN 254
            .|..||:|:|:::.||.|:::.||.:|||.|.|.:.....|..::.....|...:||.:...|..
  Fly   191 RCKAGTVDSWIVWNLTNGALHITDVTNASRTLLMNLETQAWDPVLLKTFGIREEMLPTIHSCSEI 255

Human   255 FGSVDEE---IFGVPIPIVALVADQQSAMFGECCFQTGDVKLTMGTGTFLDINTGNSLQQTTGGF 316
            ||.:..|   :.|:.:.  .::.:||:::.|:.|.:.|..|.|..:|.||..|||:....:..|.
  Fly   256 FGKITSERSPLRGMTLS--GIMGNQQASLLGQMCVKPGQTKNTYRSGCFLLCNTGDKPVFSRHGL 318

Human   317 YPLIGWKIGQE--VVCLAESNAGDTGTAIKWAQ-QLDLFTDAAETEKMAKSLEDSEGVCFVPSFS 378
            ...:.:|:|.:  .:...|......|.|:.|.| ::.:..|:.:.||.|:.:..|..|.|||:|:
  Fly   319 LTTVAYKLGPQAPTIYAIEGAVSVAGHALSWLQNKVRILPDSRDAEKYAEMVPTSGDVYFVPAFT 383

Human   379 GLQAPLNDPWACASFMGLKPSTSKYHLVRAILESIAFRNKQLYEMMKKEIHIPVRKIRADGGVCK 443
            ||.||.....|....:||...|.|.|:|||.||||.|:.:.:.|.|.:|....:.|:.|||.:..
  Fly   384 GLYAPYWRQNARGIIIGLTQFTRKNHIVRAALESICFQTRDILECMHQECGYEINKLHADGKLTT 448

Human   444 NGFVMQMTSDLINENIDRPADIDMSCLGAASLAGLAVGFWTDKEELKKLRQSEVVFKPQKKCQE- 507
            |..:||:.:|.|...:.|...:|.:..|||..|..|.|.        .|.|    |:|:|:..|
  Fly   449 NNLLMQLQADTIGMPVFRSQLMDSTAFGAAMCAAQADGV--------NLCQ----FEPEKRYYEN 501

Human   508 --YEMSLE------------NWAKAVKRSMNWYNK 528
              |:..|.            .|.:||:||:.|..|
  Fly   502 VHYDTFLATTTDVERKERYGKWKRAVERSLGWVIK 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GK5	NP_001034636.1	ASKHA_NBD_FGGY_GK5-like	20..520	CDD:466803	151/530 (28%)
Gk2	NP_647655.1	glycerol_kin	31..533	CDD:273549	155/536 (29%)