DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkm and PyK

DIOPT Version :9

Sequence 1:	XP_006243252.1	Gene:	Pkm / 25630	RGDID:	3337	Length:	591	Species:	Rattus norvegicus
Sequence 2:	NP_524448.3	Gene:	PyK / 42620	FlyBaseID:	FBgn0267385	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	336/517 - (64%)
Similarity:	410/517 - (79%)	Gaps:	1/517 - (0%)

- Green bases have known domain annotations that are detailed below.

  Rat    74 QTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSH 138
            :..|..||.|||.|||||||..||.....|.:||:|||||||.|||||::|:.:|||:||:||||
  Fly    17 EVPQNMAAGADTQLEHMCRLQFDSPVPHVRLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSH 81

  Rat   139 GTHEYHAETIKNVRAATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKIT 203
            |:|||||.|:.|||.|.:::::......|||:||||||||||||||.||||||:|||||..:|:|
  Fly    82 GSHEYHAATVANVRQAVKNYSAKLGYEHPVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKLT 146

  Rat   204 LDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGSLGSKKG 268
            .:..::||....|:::||:||..||:.|::::||||||||.|:|.|.|.|..||||||||||:||
  Fly   147 TNKEFLEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSRKG 211

  Rat   269 VNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIEN 333
            |||||..||||||||||..||.|||||:|||:||||||.||.:.|:|||||||||||||||||||
  Fly   212 VNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIEN 276

  Rat   334 HEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKP 398
            .:|:...|||:||.||||||||||||||||||||||||.||.|||:|||||||||||||||:|||
  Fly   277 QQGMHNLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKP 341

  Rat   399 RPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASS 463
            ||||||.|||||||||||||:|||||||||:||||.|.......:|||||::|:.||.:|.|.:.
  Fly   342 RPTRAEISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAG 406

  Rat   464 QSTDPLEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRG 528
             :.|...|.|:.:|||:.|..|:|::|:|.||:||.||::||||.|||||||..|||||||||||
  Fly   407 -TIDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRG 470

  Rat   529 IFPVLCKDAVLDAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPV 590
            :.|::.|:..|..|.:|||:||...:.|||..||.|.||.|:|:|||:.|||||||:|:|.|
  Fly   471 LVPLIYKEPGLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQGSGFTNTIRIVTV 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkm	XP_006243252.1	Pyruvate_Kinase	102..590	CDD:238178	320/487 (66%)
Pkm	XP_006243252.1	pyruv_kin	103..587	CDD:273424	318/483 (66%)
PyK	NP_524448.3	Pyruvate_Kinase	46..532	CDD:238178	320/486 (66%)
PyK	NP_524448.3	pyruv_kin	46..529	CDD:273424	318/483 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340669
Domainoid	1	1.000	492	1.000	Domainoid score	I352
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37650
Inparanoid	1	1.050	664	1.000	Inparanoid score	I722
OMA	1	1.010	-	-		QHG53565
OrthoDB	1	1.010	-	-		D219692at33208
OrthoFinder	1	1.000	-	-		FOG0000841
OrthoInspector	1	1.000	-	-		otm45163
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	LDO	PTHR11817
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X374
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810