DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptpn11 and csw

DIOPT Version :9

Sequence 1:NP_001171064.1 Gene:Ptpn11 / 25622 RGDID:3447 Length:597 Species:Rattus norvegicus
Sequence 2:NP_477131.1 Gene:csw / 45278 FlyBaseID:FBgn0000382 Length:945 Species:Drosophila melanogaster


Alignment Length:718 Identity:288/718 - (40%)
Similarity:370/718 - (51%) Gaps:232/718 - (32%)


- Green bases have known domain annotations that are detailed below.


  Rat    21 LTRGVDGSFLARPSK--SNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKF--ATLAELVQYY 81
            ||.....|:.|.|:.  :.|..|..:                     :||...  :||:.|....
  Fly   160 LTPSPQASYPATPTSWTATPPQFPAA---------------------FGGASCSNSTLSLLATMR 203

  Rat    82 MEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGD 146
            ::.||.                       .||||:|||||||||:.|:||:||||||||||.|||
  Fly   204 VQLHGY-----------------------TWFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGD 245

  Rat   147 FVLSVRTGDDKGESNDSKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQ 211
            |||||||.|          ||||||||.|:.||||||||.|.:|::|::|||:||||||.|||:.
  Fly   246 FVLSVRTDD----------KVTHVMIRWQDKKYDVGGGESFGTLSELIDHYKRNPMVETCGTVVH 300

  Rat   212 LKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNK 276
            |:||.|.|||.||.|.:||.:|         ||.|||||||:| ||:.:..:||.||.:|||:.|
  Fly   301 LRQPFNATRITAAGINARVEQL---------VKGGFWEEFESL-QQDSRDTFSRNEGYKQENRLK 355

  Rat   277 NRYKNILPFDHTRVVLHDGDPNEPVSDYINANII-MP---------------------------- 312
            |||:||||:|||||.|.|.:.:...::|||||.| :|                            
  Fly   356 NRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAA 420

  Rat   313 EFETKCNN---------------------------------SKPK-------------------- 324
            :.:..|:|                                 ||.|                    
  Fly   421 QTQRNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGS 485

  Rat   325 ---------------------------------------------------------KSYIATQG 332
                                                                     |:||||||
  Fly   486 SGTSGVSSVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQG 550

  Rat   333 CL----QNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDECALKEYGVMRVRNVRESAA 393
            ||    .|||.|||.||:|||:|||||||||.||||.||.:|||||...:::|..|::.|.|::.
  Fly   551 CLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENST 615

  Rat   394 HDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIVDA-- 456
            .||||||..:|      .:....|.::.|||:.|||||||:|||.||:||::|:.:|..:..|  
  Fly   616 SDYTLREFLVS------WRDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGE 674

  Rat   457 --GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIY 519
              ||:.|||||||||||||||||:::|.|...|:|.:||:.:|||||||||||:|||||||:|:|
  Fly   675 KPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVY 739

  Rat   520 MAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLVDQTSGDQSPLPPC----------TP-TPPC 573
            .||||||:||..|...|::|.:.|.|||||||:........:|||||.          || ||..
  Fly   740 YAVQHYIQTLIARKRAEEQSLQVGREYTNIKYTGEIGNDSQRSPLPPAISSISLVPSKTPLTPTS 804

  Rat   574 AEM 576
            |::
  Fly   805 ADL 807

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptpn11NP_001171064.1 SH2_N-SH2_SHP_like 5..103 CDD:198203 14/85 (16%)
SH2_C-SH2_SHP_like 111..218 CDD:198185 72/106 (68%)
PTPc 246..524 CDD:214550 163/424 (38%)
PTPc 276..523 CDD:238006 145/393 (37%)
Substrate binding. /evidence=ECO:0000250 463..469 5/5 (100%)
cswNP_477131.1 SH2_C-SH2_SHP_like 211..307 CDD:198185 72/105 (69%)
PTPc 326..744 CDD:214550 163/424 (38%)
PTPc 543..743 CDD:238006 118/205 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 246 1.000 Domainoid score I2105
eggNOG 1 0.900 - - E2759_KOG0790
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2122
Inparanoid 1 1.050 684 1.000 Inparanoid score I683
OMA 1 1.010 - - QHG52365
OrthoDB 1 1.010 - - D132255at33208
OrthoFinder 1 1.000 - - FOG0002703
OrthoInspector 1 1.000 - - otm44777
orthoMCL 1 0.900 - - OOG6_102716
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1404
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1413.740

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