Protein Alignment GABRB3 and SecCl

DIOPT Version :9

• Sequence 1: NP_000805.1
• Gene: GABRB3 / 2562
• HGNCID: 4083
• Length: 473
• Species: Homo sapiens
• Sequence 2: NP_001261986.1
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Alignment Length: 487
• Identity: 130/487 - (26%)
• Similarity: 222/487 - (45%)
• Gaps: 97/487 - (19%)

Human    48 YDIRLRP---DFGGP--PVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPL--N 105
            ||...||   |..|.  |:.|...|.:..:..::...:.:.:....|..::||||||.....  |
  Fly    57 YDRLERPFEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDN 121

Human   106 LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPL 170
            :.....::::||:|..:|.|:::|.:.|...|:.:..|.|:|.|:...|:..:..|.|:.:::|.
  Fly   122 ILGQKHLSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPF 186

Human   171 DEQNCTLEIESYGYTTDDIEFYWR-----GGDKAVTGVERIELPQFSIVEHRLVS---------- 220
            |:|.|:..:||:.|.|.|:...|.     ..|           |:..:.|:.:..
  Fly   187 DQQFCSTVLESWMYNTSDLILEWEPHTPISFD-----------PEMRLTEYNMAQFWHNTTIVQS 240

Human   221 -----RNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGI 280
                 |:..|| |.|..||.:..|||.||:::|..|:||::|..:||||||:..|||..|:.||.
  Fly   241 DGDNLRHGAFA-GNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGT 304

Human   281 TTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEK 345
            :|:|:..|:::...:.|||:.|:|..:::.:||..|:|.:|:|:||||.|:     :|::.:..|
  Fly   305 STMLSFITLSSSQSKNLPKVSYIKVSEVWFLGCTFFIFGSLVEFAFVNTIW-----RRKENIELK 364

Human   346 TAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGD--TRNSAISFDNSGIQYRKQSMP 408
            ...:|               .|:.::|.......::.|.:.:  ...|..|.||  |....:|:
  Fly   365 KVNSK---------------YIIKSTLTPRPARRQIGGSLSNESRARSCSSLDN--IVSSTESV- 411

Human   409 REGHG-------RFLG-DRSLPHKKT------------------HLRRRSSQLKIKIPDLTDVNA 447
            |.|:|       .:|. ..:||..:|                  |:.......|...|..|.:..
  Fly   412 RNGNGTVNQGFNNYLTVHPNLPIIRTECAEADTVSICSARTNNDHIVDVDKDKKDTPPTFTTMTP 476

Human   448 ------IDRWSRIVFPFTFSLFNLVYWLY-YV 472
                  |||.||.:||..|..||.:||.: ||
  Fly   477 QEIAMWIDRRSRFLFPAMFLAFNALYWTFVYV 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRB3	NP_000805.1	LIC	10..471	CDD:273305	128/484 (26%)
		Benzamidine binding, agonist. /evidence=ECO:0000269|PubMed:24909990	120..122		0/1 (0%)
		Benzamidine binding, agonist. /evidence=ECO:0000269|PubMed:24909990, ECO:0007744|PDB:4COF	180..182		1/1 (100%)
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	128/482 (27%)
		Neur_chan_LBD	44..267	CDD:280998	55/221 (25%)
		Neur_chan_memb	275..503	CDD:280999	68/250 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3673
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760