DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABRB3 and Rdl

DIOPT Version :9

Sequence 1:	NP_000805.1	Gene:	GABRB3 / 2562	HGNCID:	4083	Length:	473	Species:	Homo sapiens
Sequence 2:	NP_001261617.1	Gene:	Rdl / 39054	FlyBaseID:	FBgn0004244	Length:	608	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	181/548 - (33%)
Similarity:	273/548 - (49%)	Gaps:	124/548 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    37 VKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSG 101
            :...:|.....||.|:||::|||||.||:.:.:.||..:|||.||:||..||:|:|.|.||||..
  Fly    59 ISAILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRK 123

Human   102 IP--LNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMD 164
            .|  ..|::.:.....:|||||:|:|:|:|:.|..|..|..||:|..|::...:|:|.||:|.|:
  Fly   124 RPGVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMN 188

Human   165 LRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGA 229
            |:.:|:|.|.|.:||||:|||..||.::||.|..:|.....:|||||.::.||..:..:...||.
  Fly   189 LQYFPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQRATEINLTTGN 253

Human   230 YPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLR 294
            |.||:...:..|::||:::|.|:||.||.|:||||||:|.:|:.||||||:||||||||:.:...
  Fly   254 YSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTN 318

Human   295 ETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQK-----KLAEKTAKAKNDRS 354
            ..||||.|||:||:||..|||.||.:|||||.|.|:......::|:     |:||:..:..:..:
  Fly   319 AALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGAN 383

Human   355 KSESN---------------------------------------------RVDAHGN-------- 366
            :.::|                                             ...:||:
  Fly   384 QQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTV 448

Human   367 ----ILLTSLE---------------------VHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQS 406
                |..::::                     ||:......||   |..:.::....|.|.....
  Fly   449 SNRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGG---TLENTVNGGRGGPQSHGPG 510

Human   407 M------------------PREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNA------ 447
            .                  |.||.|.  .:.::|   .||.......|:|     |:|.
  Fly   511 PGQGGGPPGGGGGGGGGGGPPEGGGD--PEAAVP---AHLLHPGKVKKVK-----DINKLLGITP 565

Human   448 --IDRWSRIVFPFTFSLFNLVYWLYYVN 473
              ||::||||||..|..|||:||:.|::
  Fly   566 SDIDKYSRIVFPVCFVCFNLMYWIIYLH 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABRB3	NP_000805.1	LIC	10..471	CDD:273305	180/544 (33%)
		Benzamidine binding, agonist. /evidence=ECO:0000269\|PubMed:24909990	120..122		1/1 (100%)
		Benzamidine binding, agonist. /evidence=ECO:0000269\|PubMed:24909990, ECO:0007744\|PDB:4COF	180..182		1/1 (100%)
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	75/182 (41%)
Rdl	NP_001261617.1	Neur_chan_memb	274..588	CDD:397193	89/326 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101786
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720