Protein Alignment GABRB2 and HisCl1

DIOPT Version :10

• Sequence 1: NP_068711.1
• Gene: GABRB2 / 2561
• HGNCID: 4082
• Length: 512
• Species: Homo sapiens
• Sequence 2: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Alignment Length: 472
• Identity: 137/472 - (29%)
• Similarity: 217/472 - (45%)
• Gaps: 115/472 - (24%)

Human    45 KGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDN 109
            |.||....|...|.|..|..::.:.|:|.::|.:|.|...::..|:|||.||.   :|.|::...
  Fly    65 KTYDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLR---LPENMSEQY 126

Human   110 RVAD-----QLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPL 169
            |:.|     .:|.||.:|.|.||...|.:::.|..:.|:.|.|:||..::|...:|.|....||.
  Fly   127 RILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPH 191

Human   170 DEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSL 234
            |.|.|::.|||..:|.:|:.|.|...|..|.. |:|||||..|.:.......:.:|||::..|::
  Fly   192 DTQICSMMIESLSHTVEDLVFIWNMTDPLVVN-TEIELPQLDISNNYTTDCTIEYSTGNFTCLAI 255

Human   235 SFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 299
            .|.|:|.:||.:..||:||.||.::||:||||..:|..|||.||:|::||:.|.||..:::||.:
  Fly   256 VFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPV 320

Human   300 PYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKIFYKD 364
            .||||||:::..|.||||::|:|:|:||...   ||     .|.||....:::...|::     |
  Fly   321 SYVKAIDVWMSSCSVFVFLSLMEFAVVNNFM---GP-----VATKAMKGYSDENISDLD-----D 372

Human   365 IKQNGTQYRSLWDPTGNLSPTRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSEAVMGLGDPRS 429
            :|.....:|                            |:|:                    :|:.
  Fly   373 LKSALQHHR----------------------------ESII--------------------EPQY 389

Human   430 TMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIF 494
            ....:..::..|                                             ||::||.|
  Fly   390 DTFCHGHATAIY---------------------------------------------IDKFSRFF 409

Human   495 FPVVFSFFNIVYWLYYV 511
            ||..|...|||||..::
  Fly   410 FPFSFFILNIVYWTTFL 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRB2	NP_068711.1	LIC	9..510	CDD:273305	137/469 (29%)
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	61/187 (33%)
		Cys-loop	182..196	CDD:349793	6/13 (46%)
		LGIC_TM_anion	265..>351	CDD:349851	43/85 (51%)
		TM1 helix	265..288	CDD:349851	12/22 (55%)
		TM2 helix	292..316	CDD:349851	11/23 (48%)
		TM3 helix	324..350	CDD:349851	14/25 (56%)