Protein Alignment GABRB2 and pHCl-1

DIOPT Version :10

• Sequence 1: NP_068711.1
• Gene: GABRB2 / 2561
• HGNCID: 4082
• Length: 512
• Species: Homo sapiens
• Sequence 2: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Alignment Length: 664
• Identity: 133/664 - (20%)
• Similarity: 237/664 - (35%)
• Gaps: 217/664 - (32%)

Human    37 KETVDRLL--KGYDIRLRP-----DF----GGPPVA---------------VGMNIDIASIDMVS 75
            ||.:|.||  |.||.||.|     ||    ..|.:|               |.:|:.:.|:....
  Fly   338 KEILDLLLEKKRYDKRLLPPVNDEDFCCGLQSPDMATNQNARRPHNRGTLTVNVNVLLLSLASPD 402

Human    76 EVNMDYTLTMYFQQAWRDKRLSY---------NVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVH 131
            |.::.|.:.....|.|.|.||.|         |.:..:        |.:|.|||||:      :|
  Fly   403 ESSLKYEVEFLLNQQWNDPRLQYGNKSHYDFLNALHHH--------DSIWTPDTYFI------MH 453

Human   132 GVTVKNRMIRLH------PDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEF 190
            | ..|:.:|.:|      .:||:.|.:|.....:|...|..:|.|:..|:..:||..|....|::
  Fly   454 G-DFKDPIIPMHFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKY 517

Human   191 YWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFS-----TGSYPRLSLSFKLKRNIGYFILQTY 250
            .|:.|::     |..:.|..:.::..||..:....     .|:|..|.:.....|:..|:....:
  Fly   518 VWKNDED-----TLRKSPSLTTLNAYLIKNQTTACDQNSWRGNYSCLQVELTFTRDRAYYFTTVF 577

Human   251 MPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVF 315
            :|.|::...|:::||:.::|..|||.:|:||:|...|.:...|.|||.:..:.|::::...|..|
  Fly   578 IPGIILVTSSFITFWLEWNAVPARVMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCF 642

Human   316 VFMALLEYALVNYIFF-----------GRGPQRQK-----------KAAEKAASANNEKMRL--- 355
            ::.:|||:..|||:..           |..|..|:           .|:..|::|....|.:
  Fly   643 IYASLLEFVCVNYVGRKRPLHNVVYRPGENPVTQRLPAVLSRIGVILASPLASAAATPAMSMMGG 707

Human   356 ------------------------DVNKIF-----------------YKDIKQNGTQYRSLWDPT 379
                                    |..:.|                 .::::....:.::...|:
  Fly   708 ATPMSSGTPAASSSVATPGTPRITDPEEFFGGGMRWQEAHGGIIGAAVQNLRARSIKRKAARSPS 772

Human   380 GNLSP---------------------TRRTTNYDFSLYTMDPHENILLSTLEIKNEMATS----- 418
            .::||                     |.....:...|....|.|  ..|:.:::..:|||
  Fly   773 TSISPHPSGRPTEHIYEEPGGSTSGVTSTKVKFKDELKEEQPEE--AESSTKLRRSVATSTPALV 835

Human   419 ------------------------EAVMGLGDPRSTMLAYDASSIQY---------------RKA 444
                                    :..:.|..||......::.:..|               :.|
  Fly   836 VRIEAEIDPEAEDKPIQDMEMTERQLSLPLKPPRRKASRSNSPASVYSDAFENVEATPGEKRQNA 900

Human   445 GLPRHSF------GRNALERHVAQKKS-------RLRRRASQLKITIPDLTDVNAIDRWSRIFFP 496
            |.|....      |.|:...|.|....       ::|::.....|.:....||.|     ||.||
  Fly   901 GAPNEIVACTTCGGSNSPCTHSANNGCATETCFVQVRKKEPPHPIRVAKTIDVIA-----RITFP 960

Human   497 VVFSFFNIVYWLYY 510
            ..::.|.|.::::|
  Fly   961 TAYAIFLIFFFVHY 974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRB2	NP_068711.1	LIC	9..510	CDD:273305	132/662 (20%)
pHCl-1	NP_001261898.1	LIC	339..>662	CDD:455710	89/342 (26%)
		LGIC_TM	<948..975	CDD:476813	10/32 (31%)
		TM4 helix	950..971	CDD:349850	9/25 (36%)