Protein Alignment GABRB2 and Rdl

DIOPT Version :9

• Sequence 1: NP_001358656.1
• Gene: GABRB2 / 2561
• HGNCID: 4082
• Length: 512
• Species: Homo sapiens
• Sequence 2: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Alignment Length: 590
• Identity: 190/590 - (32%)
• Similarity: 286/590 - (48%)
• Gaps: 139/590 - (23%)

Human    20 AAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLT 84
            ||....|:....|:|.:   :|.....||.|:||::|||||.||:.:.:.||..:|||.||:||.
  Fly    46 AATGGGSMLGDVNISAI---LDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLD 107

Human    85 MYFQQAWRDKRLSYNVIP--LNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGT 147
            .||:|.|.|.||:|...|  ..|::.:.....:|||||:|:|:|:|:.|..|..|..||:|..|:
  Fly   108 FYFRQFWTDPRLAYRKRPGVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGS 172

Human   148 VLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSI 212
            :...:|:|.||:|.|:|:.:|:|.|.|.:||||:|||..||.::||...::|...:::|||||.:
  Fly   173 ITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRV 237

Human   213 VDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVAL 277
            :.::....::..:||:|.||:...:..|::||:::|.|:||.||.|:||||||:|.:|:.|||||
  Fly   238 LGHRQRATEINLTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVAL 302

Human   278 GITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNY-------------- 328
            |:||||||||:.:.....||||.|||:||:||..|||.||.:|||||.|.|
  Fly   303 GVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMA 367

Human   329 ---------------------------------------------------IFFGRGPQRQKKAA 342
                                                               :..|.||:......
  Fly   368 IQKIAEQKKQQLDGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHG 432

Human   343 EKAASANN---EKMRLDVNKIFYKDIKQN-GTQYRSLWDPTGNLSPTRRTTNYDFSLYTMDPHEN 403
            ..|.|..:   .|..:....|.:.:|:|| ||:..|:   .|.|....|     |.::  ||..:
  Fly   433 HHAHSHGHPHAPKQTVSNRPIGFSNIQQNVGTRGCSI---VGPLFQEVR-----FKVH--DPKAH 487

Human   404 ILLSTLE--IKNEMATSEA------------------------VMGLGDPRSTMLAYDASSIQYR 442
            ....|||  :.......::                        ..|.|||
  Fly   488 SKGGTLENTVNGGRGGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDP--------------- 537

Human   443 KAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYW 507
            :|.:|.|..       |..:.| :::.....|.||..|      ||::|||.|||.|..||::||
  Fly   538 EAAVPAHLL-------HPGKVK-KVKDINKLLGITPSD------IDKYSRIVFPVCFVCFNLMYW 588

Human   508 LYYVN 512
            :.|::
  Fly   589 IIYLH 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRB2	NP_001358656.1	LIC	9..510	CDD:273305	189/586 (32%)
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	71/182 (39%)
		Neur_chan_memb	274..588	CDD:397193	97/352 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101786
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820