Protein Alignment GABRB2 and Lcch3

DIOPT Version :10

• Sequence 1: NP_068711.1
• Gene: GABRB2 / 2561
• HGNCID: 4082
• Length: 512
• Species: Homo sapiens
• Sequence 2: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Alignment Length: 501
• Identity: 235/501 - (46%)
• Similarity: 311/501 - (62%)
• Gaps: 71/501 - (14%)

Human    36 VKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNV 100
            |.:|:..:|:||||||||:|||.|:.|||::.|||.|.:||||||||:|||..|.|||:||::|:
  Fly    40 VTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNI 104

Human   101 ------------IPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLR 153
                        |...|||....|:::|||||:|.|||.||:|.||.:|:::||..||.|.||:|
  Fly   105 FGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMR 169

Human   154 ITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLI 218
            .|||.||||||..||||.||||:||||||||..|:..||:  ...|.||...|||||:|:.|:..
  Fly   170 FTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWK--PTPVRGVEDAELPQFTIIGYETN 232

Human   219 TKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVL 283
            .:|...:||.|.||||||||:||||||:.|||:|||||.:|||||||||::|::|||||||||||
  Fly   233 DRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVL 297

Human   284 TMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEK---- 344
            |||||:|.:|.:||:|.||||||:||:.||||||.||||||.|||.::|:   |.||..:|
  Fly   298 TMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGK---RAKKKIKKVKEC 359

Human   345 -----AASANNEKMRLDVNKIFYKDIKQNGTQYRSLWDPTGNLSPTRRTTNYDFSLYTMDPHENI 404
                 ..|..:|......:.|..:|::.:..             |:.|...|:
  Fly   360 CPGKIGKSERSETCSTTEDIIELQDVRMSPI-------------PSLRRGTYN------------ 399

Human   405 LLSTLEIKNEMATSEAVMGLGD-PRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKK---S 465
              :||:     :.....|.||. |.|..:.        |..| ..||..|...:|.::.:.   .
  Fly   400 --ATLD-----SIGTETMNLGKFPPSFRIT--------RNYG-TGHSQLRRRAQRGISTRPRMLH 448

Human   466 RLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYV 511
            .|:|.||.:|.|||.:.|||.||::||:.||:.|..||:.|||:|:
  Fly   449 ALKRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFYI 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRB2	NP_068711.1	LIC	9..510	CDD:273305	234/498 (47%)
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	234/498 (47%)