DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF549 and crol

DIOPT Version :9

Sequence 1:	NP_001186224.2	Gene:	ZNF549 / 256051	HGNCID:	26632	Length:	640	Species:	Homo sapiens
Sequence 2:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster

Alignment Length:	577	Identity:	198/577 - (34%)
Similarity:	281/577 - (48%)	Gaps:	48/577 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    67 GCLHGIEAEEAPSEQTLSAQGVSQARTPKLGPSIPNAHSCEMCILVMKDILYLSEHQGTLPWQKP 131
            |.:||::.    |....:..|.:.|..|...|.....|.|::|..:.:....|..|:.....:||
  Fly   188 GGIHGVDG----SGNGGNGGGQNVALAPDGTPIATGTHVCDICGKMFQFRYQLIVHRRYHSERKP 248

Human   132 YTSVASGKWFSFGSNLQQHQNQDSGEKHIRKEESSALLLNSCKIPLSDNLFPCKDVEKDFPTILG 196
            :.....|:.|:...:|.:|.                      ||.:...:|.|......|.....
  Fly   249 FMCQVCGQGFTTSQDLTRHG----------------------KIHIGGPMFTCIVCFNVFANNTS 291

Human   197 LLQHQTTHSRQE-YAHRSRETFQQRRYKCEQVFNEKVHVTEHQRVHTGEKAYKRREYGKSLNSKY 260
            |.:|...||..: :|...          |::.|..|.|:..|.|.||||..::.:...|:...|.
  Fly   292 LERHMKRHSTDKPFACTI----------CQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKE 346

Human   261 LFVEHQRTHNAEKPYVCNICGKSFLHKQTLVGHQQRIHTRERSYVCIECGKSLSSKYSLVEHQRT 325
            ..|.|.|.|..|.|:.|:||.|||..|:..|.|.. .||.:..:.|..|||..:.|..|..|.|:
  Fly   347 HMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYM-WHTGQTPHQCDVCGKKYTRKEHLANHMRS 410

Human   326 HNGEKPYVCNVCGKSFRHKQTFVGHQQRI--HTGERPYVCMECGKSFIHSYDRIRHQRVHTGEGA 388
            |..|.|:.|.:|||||..|:.|..|   |  ||||.|:.|..|.|:|......:.|.|.||||..
  Fly   411 HTNETPFRCEICGKSFSRKEHFTNH---ILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESP 472

Human   389 YQCSECGKSFIYKQSLLDHHRIHTGERPYECKECGKAFIHKKRLLEHQRIHTGEKPYVCIICGKS 453
            ::||.|.|:|..|:.|::|.|.||||.|::|..|.|||..|..::.|.|.||||.|:.|..|.|:
  Fly   473 HRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKT 537

Human   454 FIRSSDYMRHQRIHTGERAYECSDCGKAFISKQTLLKHHKIHTRERPYECSECGKGFYLEVKLLQ 518
            |.|......|.|.|||:..:.||.|.|.|..|:.|..|.::||.:.|::|..|.|.|..:..|..
  Fly   538 FTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNN 602

Human   519 HQRIHTREQLCECNECGKVFSHQKRLLEH-QKVHTGEKPCECSECGKCFRHRTSLIQHQKVHSG- 581
            |.|.|:.:....||.|.|.|:.::.|:.| .:.|||::|..|..|||.|..:.:|:.||:.|:.
  Fly   603 HMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKG 667

Human   582 ---ERPYNCTACEKAFIYKNKLVEHQRIHTGEKPYECGKCGKAFNKRYSLVRHQKVH 635
               |||:.|..|.|.||.|..||.|.|.|:||||:.|..|.|||.:|.:|.||.|::
  Fly   668 QEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMN 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF549	NP_001186224.2	KRAB	27..67	CDD:307490	198/577 (34%)
		COG5048	223..603	CDD:227381	152/386 (39%)
		C2H2 Zn finger	224..241	CDD:275368	6/16 (38%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..298	CDD:275368	9/20 (45%)
		C2H2 Zn finger	306..326	CDD:275368	8/19 (42%)
		C2H2 Zn finger	334..355	CDD:275368	10/22 (45%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	9/19 (47%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	7/20 (35%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	10/19 (53%)
		zf-H2C2_2	600..624	CDD:316026	14/23 (61%)
		C2H2 Zn finger	615..635	CDD:275368	10/19 (53%)
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	4/19 (21%)
		C2H2 Zn finger	251..271	CDD:275368	5/41 (12%)
		C2H2 Zn finger	279..299	CDD:275368	4/19 (21%)
		COG5048	300..723	CDD:227381	170/436 (39%)
		C2H2 Zn finger	307..327	CDD:275368	6/29 (21%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	9/20 (45%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	10/22 (45%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	10/19 (53%)
		C2H2 Zn finger	704..722	CDD:275368	9/17 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910