DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdr and htl

DIOPT Version :9

Sequence 1:	NP_037194.2	Gene:	Kdr / 25589	RGDID:	2965	Length:	1343	Species:	Rattus norvegicus
Sequence 2:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster

Alignment Length:	816	Identity:	231/816 - (28%)
Similarity:	347/816 - (42%)	Gaps:	216/816 - (26%)

- Green bases have known domain annotations that are detailed below.

  Rat   481 WRHVKDFQG----GNKIEVTKNQYALIEGKNKTVSTLVIQAANVSALYKCEA--------INKAG 533
            |:.....:|    .|..|:.|:... ...:|||.:  :...||.|:....:.        .|||.
  Fly    31 WQPAVQVEGRRQMANSQEMIKDHLG-ARSQNKTPA--ITNNANQSSTSSADLDDGAADDDDNKAD 92

  Rat   534 RGERVISFHVIRGPEITVQPATQPTEQESVSLL---CTADRNTFENLTWYKLGSQATSVHMGESL 595
            ....|.|....|.|:......|:|    |.|||   |.|..|...|:|||:
  Fly    93 LPVNVSSKPYWRNPKKMSFLQTRP----SGSLLTLNCHALGNPEPNITWYR-------------- 139

  Rat   596 TPVCKNLDALWKLNGTV-----FSNSTNDILIVAFQNASLQDQGNYVCSAQDKKTKKRHCLVKQL 655
                         ||||     :.:...:...:..::....|.|||.|...:.....||  ..|:
  Fly   140 -------------NGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRH--DTQV 189

  Rat   656 VILERM--AP-MITGNLENQTTTIGETIEVVCPTSGNPTPLITWF----------KDNETLVEDS 707
            ::.:|:  .| ::||.| |.|..:..|..:.|....:.|....|.          .:|.:::.:.
  Fly   190 IVSDRVNHKPILMTGPL-NLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAED 253

  Rat   708 GIVLKDGNRNLTIRRVRKEDGGLYTCQACNVLGCARA-------ETLFIIE-----GAQEKTNLE 760
                ||   .|....||.|..|.|||...|.||.:.:       .:|.::|     |:...|:..
  Fly   254 ----KD---QLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFV 311

  Rat   761 VIILVGTAVIAMFFWLLLVIVLRTVKRA---------------------------NEGELKTGYL 798
            .|.:.|..:......|.:...:|.:|..                           :.|.:.|..:
  Fly   312 YIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIM 376

  Rat   799 SIV------------------MDPDELPLDERCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVI 845
            .:|                  .:..|.|||          |.||.||..|.||..||.||||:|:
  Fly   377 PVVRIQKQRTTVLQNGNEPAPFNEYEFPLD----------SNWELPRSHLVLGATLGEGAFGRVV 431

  Rat   846 EADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMV 910
            .|:       .....|||||:|||.|..:..:|:.|::::..||.|:|::||||.|:: .|||.|
  Fly   432 MAE-------VNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQ-NGPLYV 488

  Rat   911 IVEFCKFGNLSTYLRGKRNEFVPYKSKGARFRSGKDYVGELSVDLKRRLDSITSSQSSASSGFVE 975
            |||:...|||..:|         ||::    ..|:|.            |..:|....:....|
  Fly   489 IVEYAPHGNLKDFL---------YKNR----PFGRDQ------------DRDSSQPPPSPPAHV- 527

  Rat   976 EKSLSDVEEEEASEELYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKI 1040
                                :|.:.||.::.|:|:||::||||:||||||||||:|:|:..|:||
  Fly   528 --------------------ITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKI 572

  Rat  1041 CDFGLARDIYKDPDYVRKG-DARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPG 1104
            .|||||||| :..||.||. :.|||:||||||::.::.|..:|||||:|:|||||.:.|..|||.
  Fly   573 ADFGLARDI-QSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPT 636

  Rat  1105 VKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHEDPNQRPAFSELVEHLGNLLQANAQQDGK 1169
            :...||....|..|.||..|...:..:|..|..|||.:.:.||.|:|:||::..|||..     :
  Fly   637 IMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTK-----E 696

  Rat  1170 DYIVLPMSETLSMEEDSGLSLPTSPVSCMEEEEVCD 1205
            ||:.:.::           :|.|.|.:..|||:..|
  Fly   697 DYLDVDIA-----------NLDTPPSTSDEEEDETD 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdr	NP_037194.2	Ig	224..325	CDD:416386
		Ig strand A	224..228	CDD:409353
		Ig strand A'	234..238	CDD:409353
		Ig strand B	240..249	CDD:409353
		Ig strand C	256..261	CDD:409353
		Ig strand C'	264..266	CDD:409353
		Ig strand D	270..278	CDD:409353
		Ig strand E	286..294	CDD:409353
		Ig strand F	304..310	CDD:409353
		Ig strand G	315..321	CDD:409353
		Ig	329..417	CDD:416386
		Ig strand A	329..332	CDD:409353
		Ig strand A'	339..343	CDD:409353
		Ig strand B	345..356	CDD:409353
		Ig strand C	360..366	CDD:409353
		Ig strand C'	368..371	CDD:409353
		Ig strand D	376..379	CDD:409353
		Ig strand E	381..386	CDD:409353
		Ig strand F	394..402	CDD:409353
		Ig strand G	408..417	CDD:409353
		Ig_3	547..641	CDD:404760	23/101 (23%)
		IGc2	676..740	CDD:197706	16/73 (22%)
		Ig strand B	680..684	CDD:409353	0/3 (0%)
		Ig strand C	693..697	CDD:409353	0/3 (0%)
		Ig strand E	716..720	CDD:409353	1/3 (33%)
		Ig strand F	730..735	CDD:409353	3/4 (75%)
		VEGFR-2_TMD	755..789	CDD:375470	6/60 (10%)
		PTKc_VEGFR2	822..1163	CDD:270681	137/341 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1267..1314
htl	NP_524394.2	Ig	112..191	CDD:299845	25/111 (23%)
		IG_like	113..191	CDD:214653	25/110 (23%)
		IG_like	205..289	CDD:214653	21/91 (23%)
		PKc_like	404..692	CDD:304357	138/352 (39%)
		STYKc	416..688	CDD:214568	130/326 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810