Protein Alignment GABRA5 and ort

DIOPT Version :10

• Sequence 1: NP_000801.1
• Gene: GABRA5 / 2558
• HGNCID: 4079
• Length: 462
• Species: Homo sapiens
• Sequence 2: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Alignment Length: 502
• Identity: 144/502 - (28%)
• Similarity: 227/502 - (45%)
• Gaps: 85/502 - (16%)

Human    11 MIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGE-RITQ 74
            |:..:::..|......|:         .|.|...::.| |.||...:..|| ::||...| :.|.
  Fly     1 MVFQIIILVICTICMKHY---------AKGEFQQSLAI-TDILPEDIKRYD-KMRPPKKEGQPTI 54

Human    75 VRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLN-----NLL----ASKIWT 130
            |...:.|.....:.:..|.|..||||.|:|||.||       |||.|     .||    ...:|.
  Fly    55 VYFHVTVMGLDSIDENSMTYVADVFFAQTWKDHRL-------RLPENMTQEYRLLEVDWLKNMWR 112

Human   131 PDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYA 195
            ||:||.|.|......||.||..:.|..|.|:||.::||:...|.|....:|.|...|.|:..|.:
  Fly   113 PDSFFKNAKSVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLS 177

Human   196 YPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYF 260
            :...::::.|   ...:.:|.::...|.|..|:...........|||.:|.:...|.|||::.|:
  Fly   178 HTTDDLIFQW---DPTTPLVVDENIELPQVALIRNETADCTQVYSTGNFTCLEVVFTLKRRLVYY 239

Human   261 VIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIA 325
            |..||:|..|.||:|.||||:..|:.|||...|||::||::|....:::|||.|:|..|:|.|::
  Fly   240 VFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMS 304

Human   326 VCYAFVFSALIEFATVNY------------FTKRGWAWDG-KKALEAA----------------- 360
            ||..|||.||:|:..:|.            :..:..|.|| ||..|.|
  Fly   305 VCTVFVFMALMEYCLINIVLSDTPIPKPMAYPPKPVAGDGPKKEGEGAPPGGSNSTASKQQATML 369

Human   361 -----KIKKKREVILNKSTN---AFTTGKMSHPPN------IPKEQTPAGTSNTTSVSVKPSE-- 409
                 ||:|..::....:.|   ..||.::..||.      ||::::....:.|.:....|.:
  Fly   370 PLADEKIEKIEKIFDEMTKNRRIVTTTRRVVRPPLDADGPWIPRQESRIILTPTIAPPPPPPQPA 434

Human   410 --------EKTSESKKTYNSISKIDKMSRIVFPVLFGTFNLVYWATY 448
                    .|.:.:::.......||:.||::||.||.:.|.:||..:
  Fly   435 APEPELPKPKLTPAQERLKRAIYIDRSSRVLFPALFASLNGIYWCVF 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRA5	NP_000801.1	LGIC_ECD_GABAAR_A5	58..256	CDD:349839	63/207 (30%)
		Cys-loop	173..187	CDD:349839	4/13 (31%)
		LGIC_TM_GABAAR_alpha	259..445	CDD:349854	69/239 (29%)
		TM1 helix	259..282	CDD:349854	13/22 (59%)
		TM2 helix	286..310	CDD:349854	9/23 (39%)
		TM3 helix	318..344	CDD:349854	12/37 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..412		8/50 (16%)
		TM4 helix	421..445	CDD:349854	9/23 (39%)
ort	NP_524406.1	LIC	31..481	CDD:455710	137/460 (30%)
		LGIC_ECD_HisCl	51..235	CDD:349793	58/193 (30%)
		Cys-loop	155..169	CDD:349793	4/13 (31%)