Protein Alignment GABRA5 and HisCl1

DIOPT Version :10

• Sequence 1: NP_000801.1
• Gene: GABRA5 / 2558
• HGNCID: 4079
• Length: 462
• Species: Homo sapiens
• Sequence 2: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Alignment Length: 403
• Identity: 129/403 - (32%)
• Similarity: 195/403 - (48%)
• Gaps: 56/403 - (13%)

Human    60 YDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQR----LPL 120
            ||....|.|..:.|.|...:.|.|...:::..|.|..|:|..|||:|.|||....|..    |.:
  Fly    67 YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDV 131

Human   121 NNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAH 185
            :.|  ..||.||.||.|.||...|.|:.||..|.|..|.||||..:||:...|.|:.|.:|.|..
  Fly   132 DWL--HSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQ 194

Human   186 ACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAH 250
            .|.:...|.::...::|::|  ..|..:||..: ..|.|..:.........|..|||.:|.:...
  Fly   195 ICSMMIESLSHTVEDLVFIW--NMTDPLVVNTE-IELPQLDISNNYTTDCTIEYSTGNFTCLAIV 256

Human   251 FHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVA 315
            |:|:|::||.:..||:|..:.|::|.:|||:..|::|||...|||::||:.|.:..::.|||.|:
  Fly   257 FNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVS 321

Human   316 YATAMDWFIAVCYAFVFSALIEFATVNYF-----TK--RGWAWDGKKALEAAK--IKKKREVILN 371
            |..|:|.:::.|..|||.:|:|||.||.|     ||  :|::.:....|:..|  ::..||.|:.
  Fly   322 YVKAIDVWMSSCSVFVFLSLMEFAVVNNFMGPVATKAMKGYSDENISDLDDLKSALQHHRESIIE 386

Human   372 KSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYNSISKIDKMSRIVFPVL 436
            ...:.|..|                  :.|::                    .|||.||..||..
  Fly   387 PQYDTFCHG------------------HATAI--------------------YIDKFSRFFFPFS 413

Human   437 FGTFNLVYWATYL 449
            |...|:|||.|:|
  Fly   414 FFILNIVYWTTFL 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRA5	NP_000801.1	LGIC_ECD_GABAAR_A5	58..256	CDD:349839	65/199 (33%)
		Cys-loop	173..187	CDD:349839	5/13 (38%)
		LGIC_TM_GABAAR_alpha	259..445	CDD:349854	58/194 (30%)
		TM1 helix	259..282	CDD:349854	9/22 (41%)
		TM2 helix	286..310	CDD:349854	9/23 (39%)
		TM3 helix	318..344	CDD:349854	12/25 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..412		3/34 (9%)
		TM4 helix	421..445	CDD:349854	10/23 (43%)
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	61/188 (32%)
		Cys-loop	182..196	CDD:349793	5/13 (38%)
		LGIC_TM_anion	265..>351	CDD:349851	36/85 (42%)
		TM1 helix	265..288	CDD:349851	9/22 (41%)
		TM2 helix	292..316	CDD:349851	9/23 (39%)
		TM3 helix	324..350	CDD:349851	12/25 (48%)