Protein Alignment GABRA5 and alka

DIOPT Version :10

• Sequence 1: NP_000801.1
• Gene: GABRA5 / 2558
• HGNCID: 4079
• Length: 462
• Species: Homo sapiens
• Sequence 2: NP_610619.2
• Gene: alka / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Alignment Length: 466
• Identity: 126/466 - (27%)
• Similarity: 210/466 - (45%)
• Gaps: 71/466 - (15%)

Human    24 LSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTD--IYVTSFGP 86
            :|...||..|..|.. .|.:.|.|...|::  |...|...:||. .::.:.|..|  |:|.....
  Fly    11 ISFGLGFILMWLSEA-TEAHMNYTAKPRVV--LPPNYVKEIRPP-SKKGSPVIVDFSIFVVDINS 71

Human    87 VSDTEMEYTIDVFFRQSWKDERLR-----FKGPMQRLPLNNLLASKIWTPDTFFHNGK----KSI 142
            ::..:|::.:|:|..|.|.:.||.     |:.....:.|...:....|.||.:|.|.|    .::
  Fly    72 INVEDMDFRVDMFIHQRWLESRLEIPDDIFEEGDDYVTLLPEVFENFWQPDPYFLNSKIAEIATL 136

Human   143 AHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTN 207
            .|..|:    :.|..:.|:.|..|:.....|.|:.:.:|||...||:...|::..|.:|...|::
  Fly   137 THKFTS----VTLYKNKTVRYAARMHAIIACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLRWSD 197

Human   208 GSTKSVVVAEDGSRLNQYHLMGQTVGTEN----ISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPC 268
                |.|......:|.||:| ||.:..|.    :....|.::.:|.:|..:|:||:.:|||:.|.
  Fly   198 ----SGVTLNPELKLLQYNL-GQPLELEESDGYMPEKVGNFSRLTVYFRFERQIGHHLIQTFAPS 257

Human   269 IMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFS 333
            .:.|:||..||||..:::|.|....||.:||:.|:...|  .:|.|||..|:|.::|.|...||:
  Fly   258 SLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFTGA--DIPPVAYVKALDLWMAGCMLSVFA 320

Human   334 ALIEFATVNYFTKRGWAWDGKKALEAA---KIKKKREVILNKSTN---------------AFTTG 380
            ||.||..|             |.|:..   ::.:..:|:..:.:|               |..:.
  Fly   321 ALAEFVVV-------------KVLDVQYQYQVNRIPKVLPMRISNMEKGQCATVASWEGGAVRSR 372

Human   381 KMSHPPNIPKEQT-------PAGTSNTTSVSVKPSEEKTSESKKTYNSISKIDKMSRIVFPVLFG 438
            |.:..|..|.:.:       |......:.:||..::..|...|..:.   :|||:||.|||:||.
  Fly   373 KATQTPTTPGQTSLQGNGGPPKPARRQSLLSVAWTDTDTGVEKIMWR---EIDKVSRAVFPILFF 434

Human   439 TFNLVYWATYL 449
            .|.|:||...|
  Fly   435 VFVLLYWPILL 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRA5	NP_000801.1	LGIC_ECD_GABAAR_A5	58..256	CDD:349839	51/212 (24%)
		Cys-loop	173..187	CDD:349839	5/13 (38%)
		LGIC_TM_GABAAR_alpha	259..445	CDD:349854	59/210 (28%)
		TM1 helix	259..282	CDD:349854	10/22 (45%)
		TM2 helix	286..310	CDD:349854	8/23 (35%)
		TM3 helix	318..344	CDD:349854	11/25 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..412		6/41 (15%)
		TM4 helix	421..445	CDD:349854	12/23 (52%)
alka	NP_610619.2	LIC	8..441	CDD:455710	123/460 (27%)