Protein Alignment GABRA5 and Lcch3

DIOPT Version :10

• Sequence 1: NP_000801.1
• Gene: GABRA5 / 2558
• HGNCID: 4079
• Length: 462
• Species: Homo sapiens
• Sequence 2: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Alignment Length: 482
• Identity: 168/482 - (34%)
• Similarity: 237/482 - (49%)
• Gaps: 88/482 - (18%)

Human    39 KDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQS 103
            ||.....:...|:.:..:|.|||.||||..|.....|..|:.:.||..:|:..|:|||.::..|.
  Fly    30 KDVLAGRLENVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQY 94

Human   104 WKDERLRFK------------GPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLE 156
            |:||||.|.            |....|.|:...|.|||.|||||.|.|.|..|::|..|||:||.
  Fly    95 WRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLG 159

Human   157 DDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSR 221
            .||.:.|.||.|.:..|.|.|..:|:|:..|.::..||.|..|:||..|.....:.|..||
  Fly   160 GDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPTPVRGVEDAE---- 220

Human   222 LNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESV 286
            |.|:.::|..........:||.|..::..|.|:|.|||||.|||||.|:.|:||.||||:|.|:.
  Fly   221 LPQFTIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEAT 285

Human   287 PARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAW 351
            .||...|:||||||||:|...|:|||:::|..|:|.::.:|:.|||:||:|:|.|||      .:
  Fly   286 SARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNY------TY 344

Human   352 DGKKALEAAKIKKKREVI---LNKSTNAFTTG-----------KMSHPPNIPKEQTPAGTSNTT- 401
            .||:|.:  ||||.:|..   :.||..:.|..           :||..|::.:     ||.|.|
  Fly   345 WGKRAKK--KIKKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRR-----GTYNATL 402

Human   402 ------------------------------------SVSVKPS-----EEKTSESKKT---YNSI 422
                                                .:|.:|.     :...|..|.|   ...:
  Fly   403 DSIGTETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIKATIPKIKDV 467

Human   423 SKIDKMSRIVFPVLFGTFNLVYWATYL 449
            :.|||.||::||:.|..|||.||..|:
  Fly   468 NIIDKYSRMIFPISFLAFNLGYWLFYI 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRA5	NP_000801.1	LGIC_ECD_GABAAR_A5	58..256	CDD:349839	76/209 (36%)
		Cys-loop	173..187	CDD:349839	5/13 (38%)
		LGIC_TM_GABAAR_alpha	259..445	CDD:349854	82/244 (34%)
		TM1 helix	259..282	CDD:349854	16/22 (73%)
		TM2 helix	286..310	CDD:349854	13/23 (57%)
		TM3 helix	318..344	CDD:349854	12/25 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..412		10/87 (11%)
		TM4 helix	421..445	CDD:349854	11/23 (48%)
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	167/479 (35%)