DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Map3k12 and slpr

DIOPT Version :9

Sequence 1:	NP_037187.1	Gene:	Map3k12 / 25579	RGDID:	3988	Length:	888	Species:	Rattus norvegicus
Sequence 2:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster

Alignment Length:	983	Identity:	242/983 - (24%)
Similarity:	367/983 - (37%)	Gaps:	297/983 - (30%)

- Green bases have known domain annotations that are detailed below.

  Rat   152 EVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLR-----------KLKHPN 205
            |:.:.|:...:.:|||....|..|.:.|||||:|......|.|::.:|           .|||.|
  Fly   123 EIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHEN 187

  Rat   206 IITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLH---KIIH 267
            |...:|||.... .|::||:...|.|..:| ||: :.|.:||:|::.||.||||||..   .|||
  Fly   188 IAALRGVCLNTK-LCLVMEYARGGSLNRIL-AGK-IPPDVLVNWAIQIARGMNYLHNEAPMSIIH 249

  Rat   268 RDLKSPNMLITYDDV---------VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEK 323
            |||||.|:|| |:.:         :||:|||.::|:.: :.:||.|||.|||.||||.....|:.
  Fly   250 RDLKSSNVLI-YEAIEGNHLQQKTLKITDFGLAREMYN-TQRMSAAGTYAWMPPEVISVSTYSKF 312

  Rat   324 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNRKPRNRP 388
            .|:||:||:||||:|||.|||..|..::.:||..|:|.||:|.:||:.:..|::.||...|..||
  Fly   313 SDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRP 377

  Rat   389 SFRQILLHLD-IASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREEL 452
            .|::||..|: ||.:....||||::...|..||:|:......::.:......:||||  |.:||.
  Fly   378 GFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIEEEL--RNKEEQ 440

  Rat   453 RHALDIREHYERKLERANNLYM-ELNALMLQLELKERELLRREQALERRCPGLLKSHTSR----- 511
            .    :|...|:: |:||.|.: |.|     |..:||.|:.||..:.:..|...|....:
  Fly   441 L----LRVQNEQR-EKANLLKIREQN-----LRERERVLIERELVMLQPVPSKRKHKKGKKNKPL 495

  Rat   512 --SLLHG--NTMEKLIKKRNVPQKLSPHSKR--------------PDIL--KTESLLPKLDAALS 556
              ||..|  :|:..:..|...|...|....|              |..:  :..||||   :.||
  Fly   496 QISLPTGFRHTITAVRDKAEQPGSPSFSGLRIVALTDGHKGKTWGPSTMHQRERSLLP---SQLS 557

  Rat   557 GVGLPGCP----------KAPPSPGRSRRGKTRHRKASAKGSCGDLPGLRAALPPHEPGGLGSPG 611
            | |.|..|          |:.|:..:.::.:.:.:.||             ..||...|.||..|
  Fly   558 G-GQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQQVAS-------------LTPPPGLGILGGSG 608

  Rat   612 GLGVGPTAWDASPPALRGL------------------------------------------HHDL 634
            |.|..|    |:|....|:                                          :::.
  Fly   609 GAGGTP----ATPLLYPGIPIILTRPNNNNIGNCKAITTTITTTTTTTTNNNNNNNNSISANNNN 669

  Rat   635 LLRKMS-------------SSSPDLLSAALGARGRGATGGARDPGSP------------------ 668
            .|..:|             :|.|:.:...  ..||..:..:....||
  Fly   670 QLNNISTINSNNNNNQTNLTSQPNTIIVL--QNGRNNSNSSTTSQSPAKIYHRARSQEYGLDHPL 732

  Rat   669 ---PPP---------QGDTPPS------------EGSAPGSTSPDSPGGAKGEPP---------- 699
               |||         :.||..|            ..:|.|:......||:.|..|
  Fly   733 AYQPPPLYLVTDDSSETDTVASPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAVGRKKHSLD 797

  Rat   700 -----PPVGPGEGVGL---------------------------LGTGREGTTGRGGSRAGYQHLT 732
                 ||........|                           :.:.....:...|....|...|
  Fly   798 SSSHHPPANGSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVNSKSSGDLTMYNSST 862

  Rat   733 P------------------------AALLYRAAVTRSQKRGISSEEE---------EGEVDSEVE 764
            |                        :........||.::.|.:.:|:         :.:.|.|.:
  Fly   863 PLTARDCDDAEEAFEGGRFQRNFSGSQFPRHCFFTRQEEEGEAEDEDAVAAEVDTADADADDECQ 927

  Rat   765 LPPSQRWPQGPNMRQSLSTFSS---ENP-----------SDVEEGTAS---------EPSPSGTP 806
            :|.||........|:|..||.|   |.|           ||:...:||         .||.|.:.
  Fly   928 VPASQMRQNSTTSRKSSVTFQSVSFEEPDFVATPRTTARSDLYTSSASISFATYRSASPSLSSSS 992

  Rat   807 EVGSTNTDERPDERSDDMCSQGSEIPLDLPTSEVVPERETSSLPMQHQDDQGPNPEDSDCDSTEL 871
            ...|.:......|..:....|.:.|.......:|.|..:...|..|.|..|..|.:..  ....:
  Fly   993 TTASASPSIASTEAVNGYHMQENSILNTRRMQDVQPHPDVIKLRAQEQRQQTKNQKKQ--RPKHI 1055

  Rat   872 DNSNSIDA 879
            ..|.|::|
  Fly  1056 TKSKSVEA 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Map3k12	NP_037187.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..104
		STKc_MAP3K12_13	164..400	CDD:270961	108/259 (42%)
		TyrKc	165..397	CDD:197581	107/254 (42%)
		Leucine-zipper 1	423..444		2/20 (10%)
		Leucine-zipper 2	476..497		7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	557..620		17/72 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..731		21/160 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	743..888		37/169 (22%)
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	107/261 (41%)
		STKc_MLK	134..389	CDD:270963	108/259 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010